# INS

> protein-coding gene in Homo sapiens

**Wikidata**: [Q21163221](https://www.wikidata.org/wiki/Q21163221)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/INS_(gene))  
**Source**: https://4ort.xyz/entity/ins-q21163221


## References

1. ensembl Release 106
2. Ensembl Release 87
3. Q20641742
4. Online Mendelian Inheritance in Man
5. [Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect?](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308)
6. [Insulin and IGF-1 increase mitogenesis and glucose metabolism in the multiple myeloma cell line, RPMI 8226](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308)
7. [A novel domain of caveolin-2 that controls nuclear targeting: regulation of insulin-specific ERK activation and nuclear translocation by caveolin-2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308)
8. [Regulation of the Akt/Glycogen synthase kinase-3 axis by insulin-like growth factor-II via activation of the human insulin receptor isoform-A](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308)
9. [Insulin and glucocorticoids differentially regulate leptin transcription and secretion in brown adipocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308)
10. [Insulin signalling and the regulation of glucose and lipid metabolism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308)
11. [Insulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308)
12. [Insulin-induced activation of NADPH-dependent H2O2 generation in human adipocyte plasma membranes is mediated by Galphai2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308)
13. [Insulin and IGF-1 increase mitogenesis and glucose metabolism in the multiple myeloma cell line, RPMI 8226](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308)
14. [Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308)
15. [Extracellular PBEF/NAMPT/visfatin activates pro-inflammatory signalling in human vascular smooth muscle cells through nicotinamide phosphoribosyltransferase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308)
16. [Binding of human, porcine and bovine insulin to insulin receptors from human brain, muscle and adipocytes and to expressed recombinant alternatively spliced insulin receptor isoforms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308)
17. [Insulin stimulates glucose transport via nitric oxide/cyclic GMP pathway in human vascular smooth muscle cells](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P01308)
18. [A structurally abnormal insulin causing human diabetes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308)
19. [Insulin-dependent activation of endothelial nitric oxide synthase is impaired by O-linked glycosylation modification of signaling proteins in human coronary endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308)
20. [Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308)
21. [Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308)
22. [Effects of Insulin on Wound Healing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308)
23. [PSM, a mediator of PDGF-BB-, IGF-I-, and insulin-stimulated mitogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308)
24. [Milk intake and feeding behavior in the first week of life and its relationship to cord blood ghrelin, leptin, and insulin concentrations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308)
25. [Intravenous insulin decreases protein breakdown in infants on extracorporeal membrane oxygenation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308)
26. [Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308)
27. [Insulin decreases hepatic acute phase protein levels in severely burned children](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308)
28. [Insulin decreases the secretion of apoB-100 from hepatic HepG2 cells but does not decrease the secretion of apoB-48 from intestinal CaCo-2 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308)
29. [Activation of the insulin receptor by insulin and a synthetic peptide leads to divergent metabolic and mitogenic signaling and responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308)
30. [Effect of intravenous insulin treatment on in vivo whole body leucine kinetics and oxygen consumption in insulin-deprived type I diabetic patients](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308)
31. [Neuroprotection of insulin against oxidative stress-induced apoptosis in cultured retinal neurons: involvement of phosphoinositide 3-kinase/Akt signal pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308)
32. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308)
33. [Resistin in Dairy Cows: Plasma Concentrations during Early Lactation, Expression and Potential Role in Adipose Tissue](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308)
34. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:C9JNR5)
35. [Glucagon regulation of plasma ketone body concentration in human diabetes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308)
36. [Insulin stimulates glucose transport via nitric oxide/cyclic GMP pathway in human vascular smooth muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308)
37. [Differential gene expression induced by insulin and insulin-like growth factor-II through the insulin receptor isoform A](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308)
38. [Bovine and human insulin activate CD8+-autoreactive CTL expressing both type 1 and type 2 cytokines in C57BL/6 mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308)
39. [Glucose tolerance is associated with differential expression of microRNAs in skeletal muscle: results from studies of twins with and without type 2 diabetes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308)
40. [Insulin and nitric oxide stimulates glucose transport in human placenta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308)
41. [Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01308)
42. HomoloGene build68
43. [Orthologous MAtrix](https://omabrowser.org/oma/vps/P01308/)
44. UniProt
45. The dynamic plasticity of insulin production in β-cells.
46. [ClinGen](https://search.clinicalgenome.org/kb/gene-validity/9c21ba4d-785f-486f-84f8-511b9c89c137--2020-05-13T16:00:00)
47. [ClinGen](https://search.clinicalgenome.org/kb/gene-validity/CGGV:assertion_9c21ba4d-785f-486f-84f8-511b9c89c137-2020-05-13T160000.000Z)
48. [ClinGen](https://search.clinicalgenome.org/kb/gene-validity/c5224322-637e-40a8-89eb-d44e01536f25--2020-05-13T16:00:00)
49. [ClinGen](https://search.clinicalgenome.org/kb/gene-validity/CGGV:assertion_c5224322-637e-40a8-89eb-d44e01536f25-2020-05-13T160000.000Z)
50. [Open Targets Platform](https://platform.opentargets.org/evidence/ENSG00000254647/EFO_0009650)