# Inositol 1,4,5-trisphosphate receptor type 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21107812](https://www.wikidata.org/wiki/Q21107812)  
**Source**: https://4ort.xyz/entity/inositol-1-4-5-trisphosphate-receptor-type-1


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q14643)
4. Q20641742
5. [Swiss-Prot](http://www.uniprot.org/uniprot/P11881.txt?version=182)
6. [IRBIT suppresses IP3 receptor activity by competing with IP3 for the common binding site on the IP3 receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643)
8. [Induction of inositol 1,4,5 trisphosphate receptor genes by ionizing radiation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14643&geneProductId=UniProtKB:Q14643)
9. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14643&geneProductId=UniProtKB:Q14643)
10. [Molecular cloning of a cDNA for the human inositol 1,4,5-trisphosphate receptor type 1, and the identification of a third alternatively spliced variant](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643)
11. [An IRBIT homologue lacks binding activity to inositol 1,4,5-trisphosphate receptor due to the unique N-terminal appendage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643)
12. [The Bcl-2 protein family member Bok binds to the coupling domain of inositol 1,4,5-trisphosphate receptors and protects them from proteolytic cleavage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643)
13. [Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643)
14. [The homocysteine-inducible endoplasmic reticulum (ER) stress protein Herp counteracts mutant α-synuclein-induced ER stress via the homeostatic regulation of ER-resident calcium release channel proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643)
15. [Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643)
16. [Mitochondria-associated endoplasmic reticulum membrane (MAM) integrity is required for insulin signaling and is implicated in hepatic insulin resistance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643)
17. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643)
18. [Induction of inositol 1,4,5 trisphosphate receptor genes by ionizing radiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643)
19. [Distinct localization and function of (1,4,5)IP(3) receptor subtypes and the (1,3,4,5)IP(4) receptor GAP1(IP4BP) in highly purified human platelet membranes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643)
20. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14643&geneProductId=UniProtKB:Q14643)
21. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643)
22. [Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643)
23. [Role of the inositol 1,4,5-trisphosphate receptor/Ca2+-release channel in autophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643)
24. [The human type 1 inositol 1,4,5-trisphosphate receptor from T lymphocytes. Structure, localization, and tyrosine phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14643)
25. ensembl Release 93
26. Transporter Classification database