# Inositol 1,4,5-trisphosphate receptor, type 1

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28558474](https://www.wikidata.org/wiki/Q28558474)  
**Source**: https://4ort.xyz/entity/inositol-1-4-5-trisphosphate-receptor-type-1-q28558474


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P29994)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994)
5. [Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994)
6. [Functional characterization of mammalian inositol 1,4,5-trisphosphate receptor isoforms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994)
7. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994)
8. [Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994)
9. [Junctional membrane inositol 1,4,5-trisphosphate receptor complex coordinates sensitization of the silent EGF-induced Ca2+ signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994)
10. [Involvement of the p97-Ufd1-Npl4 complex in the regulated endoplasmic reticulum-associated degradation of inositol 1,4,5-trisphosphate receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994)
11. [Inositol 1, 4, 5-trisphosphate receptor interacts with the SNARE domain of syntaxin 1B](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994)
12. [The homocysteine-inducible endoplasmic reticulum (ER) stress protein Herp counteracts mutant α-synuclein-induced ER stress via the homeostatic regulation of ER-resident calcium release channel proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994)
13. [Association of the type 1 inositol (1,4,5)-trisphosphate receptor with 4.1N protein in neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994)
14. [Domoic acid enhances Bcl-2-calcineurin-inositol-1,4,5-trisphosphate receptor interactions and delayed neuronal death in rat brain slices](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994)
15. [Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994)
16. [Microtubule-dependent redistribution of the type-1 inositol 1,4,5-trisphosphate receptor in A7r5 smooth muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994)
17. [P400 protein is one of the major substrates for Ca2+/calmodulin-dependent protein kinase II in the postsynaptic density-enriched fraction isolated from rat cerebral cortex, hippocampus and cerebellum](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994)
18. [Ca2+ stores in Purkinje neurons: endoplasmic reticulum subcompartments demonstrated by the heterogeneous distribution of the InsP3 receptor, Ca(2+)-ATPase, and calsequestrin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994)
19. [Inositol 1,4,5 trisphosphate receptor and chromogranin B are concentrated in different regions of the hippocampus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994)
20. [Calpain-cleaved type 1 inositol 1,4,5-trisphosphate receptor (InsP(3)R1) has InsP(3)-independent gating and disrupts intracellular Ca(2+) homeostasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994)
21. [Calcium signalling from the type I inositol 1,4,5-trisphosphate receptor is required at early phase of liver regeneration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994)
22. [Potentiation of NGF-induced neurite outgrowth in PC12 cells by papaverine: role played by PLC-γ, IP3 receptors.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994)
23. [Ins(1,4,5)P3 receptor type 1 associates with AKAP9 (AKAP450 variant) and protein kinase A type IIbeta in the Golgi apparatus in cerebellar granule cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994)
24. [Functional Role of Intracellular Calcium Receptor Inositol 1,4,5-Trisphosphate Type 1 in Rat Hippocampus after Neonatal Anoxia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994)
25. [Polycystin 2 interacts with type I inositol 1,4,5-trisphosphate receptor to modulate intracellular Ca2+ signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994)
26. [Fragmented Inositol 1,4,5-Trisphosphate Receptors Retain Tetrameric Architecture and Form Functional Ca2+ Release Channels](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994)
27. [Regulation of Inositol 1,4,5-Trisphosphate Receptors by cAMP Independent of cAMP-dependent Protein Kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994)
28. [Hypoxia modulates gene expression of IP3 receptors in rodent cerebellum](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994)
29. [Enhanced hypoxic preconditioning by isoflurane: signaling gene expression and requirement of intracellular Ca2+ and inositol triphosphate receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29994)
30. ensembl Release 106