# Inositol 1,4,5-trisphosphate receptor 1

> mammalian protein found in Mus musculus

**Wikidata**: [Q21495559](https://www.wikidata.org/wiki/Q21495559)  
**Source**: https://4ort.xyz/entity/inositol-1-4-5-trisphosphate-receptor-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P11881)
3. Q20641742
4. [The Bcl-2 protein family member Bok binds to the coupling domain of inositol 1,4,5-trisphosphate receptors and protects them from proteolytic cleavage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881)
5. [The Stability and Expression Level of Bok Are Governed by Binding to Inositol 1,4,5-Trisphosphate Receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881)
6. [Irbit Mediates Synergy Between Ca2+ and cAMP Signaling Pathways During Epithelial Transport in Mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881)
7. [Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/selenoprotein K complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881)
8. [Inositol 1, 4, 5-trisphosphate receptor interacts with the SNARE domain of syntaxin 1B](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881)
9. [Carbonic anhydrase-related protein is a novel binding protein for inositol 1,4,5-trisphosphate receptor type 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881)
10. [Mouse trp2, the homologue of the human trpc2 pseudogene, encodes mTrp2, a store depletion-activated capacitative Ca2+ entry channel](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881)
11. [Signaling complex formation of phospholipase Cbeta4 with metabotropic glutamate receptor type 1alpha and 1,4,5-trisphosphate receptor at the perisynapse and endoplasmic reticulum in the mouse brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881)
12. [Genetic evidence supporting caveolae microdomain regulation of calcium entry in endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881)
13. [Protein 4.1N is required for translocation of inositol 1,4,5-trisphosphate receptor type 1 to the basolateral membrane domain in polarized Madin-Darby canine kidney cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881)
14. [Calcium-dependent interaction of calcineurin with Bcl-2 in neuronal tissue](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881)
15. [Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881)
16. [IRAG is essential for relaxation of receptor-triggered smooth muscle contraction by cGMP kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881)
17. [Ankyrin-B coordinates the Na/K ATPase, Na/Ca exchanger, and InsP3 receptor in a cardiac T-tubule/SR microdomain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881)
18. [The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881)
19. [Subtype-specific and ER lumenal environment-dependent regulation of inositol 1,4,5-trisphosphate receptor type 1 by ERp44](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881)
20. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881)
21. [Tyr-167/Trp-168 in type 1/3 inositol 1,4,5-trisphosphate receptor mediates functional coupling between ligand binding and channel opening](http://www.ebi.ac.uk/QuickGO/annotations?protein=P11881&geneProductId=UniProtKB:P11881)
22. [Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors](http://www.ebi.ac.uk/QuickGO/annotations?protein=P11881&geneProductId=UniProtKB:P11881)
23. [Mutational analysis of the ligand binding site of the inositol 1,4,5-trisphosphate receptor](http://www.ebi.ac.uk/QuickGO/annotations?protein=P11881&geneProductId=UniProtKB:P11881)
24. [Tyr-167/Trp-168 in type 1/3 inositol 1,4,5-trisphosphate receptor mediates functional coupling between ligand binding and channel opening](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881)
25. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881)
26. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P11881&geneProductId=UniProtKB:P11881)
27. [The subtypes of the mouse inositol 1,4,5-trisphosphate receptor are expressed in a tissue-specific and developmentally specific manner](http://www.ebi.ac.uk/QuickGO/annotations?protein=P11881&geneProductId=UniProtKB:P11881)
28. [The subtypes of the mouse inositol 1,4,5-trisphosphate receptor are expressed in a tissue-specific and developmentally specific manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881)
29. [Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881)
30. [Mutational analysis of the ligand binding site of the inositol 1,4,5-trisphosphate receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881)
31. [Calcium stores regulate the polarity and input specificity of synaptic modification](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881)
32. [Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881)
33. [Differential distribution of inositol trisphosphate receptor isoforms in mouse oocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881)
34. [Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum](http://www.ebi.ac.uk/QuickGO/annotations?protein=P11881&geneProductId=UniProtKB:P11881)
35. [Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P11881&geneProductId=UniProtKB:P11881)
36. [Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881)
37. [Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881)
38. [Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881)
39. [Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P11881&geneProductId=UniProtKB:P11881)
40. ensembl Release 106