# infantile-onset ascending hereditary spastic paralysis

> Infantile-onset ascending hereditary spastic paralysis (IAHSP) is a very rare motor neuron disease characterized by severe spasticity of the lower limbs in early life, progression of spasticity to the upper limbs in late childhood, and dysarthria

**Wikidata**: [Q3363624](https://www.wikidata.org/wiki/Q3363624)  
**Source**: https://4ort.xyz/entity/infantile-onset-ascending-hereditary-spastic-paralysis


## References

1. Monarch Disease Ontology release 2018-06-29
2. UniProt
3. Infantile-onset ascending hereditary spastic paralysis is associated with mutations in the alsin gene
4. [Open Targets Platform](https://platform.opentargets.org/evidence/ENSG00000003393/MONDO_0011797)