# Hypoxia inducible factor 1 subunit alpha

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28557790](https://www.wikidata.org/wiki/Q28557790)  
**Source**: https://4ort.xyz/entity/hypoxia-inducible-factor-1-subunit-alpha


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O35800)
3. Q20641742
4. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35800)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35800)
6. [PKB/Akt activation inhibits p53-mediated HIF1A degradation that is independent of MDM2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35800)
7. [Astrocyte responses to injury: VEGF simultaneously modulates cell death and proliferation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35800)
8. [Ref-1/Ape is critical for formation of the hypoxia-inducible transcriptional complex on the hypoxic response element of the rat pulmonary artery endothelial cell VEGF gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35800)
9. [Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-1/CREB and increased expression of glycolytic enzymes, [...]](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35800)
10. [Two splice variants of the hypoxia-inducible factor HIF-1alpha as potential dimerization partners of ARNT2 in neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35800)
11. [A variant of nuclear localization signal of bipartite-type is required for the nuclear translocation of hypoxia inducible factors (1alpha, 2alpha and 3alpha)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35800)
12. [Regulation of tyrosine hydroxylase promoter activity by the von Hippel-Lindau tumor suppressor protein and hypoxia-inducible transcription factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35800)
13. [Perivenous expression of the mRNA of the three hypoxia-inducible factor alpha-subunits, HIF1alpha, HIF2alpha and HIF3alpha, in rat liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35800)
14. [Hypoxia-inducible factor regulation of ANK expression in nucleus pulposus cells: possible implications in controlling dystrophic mineralization in the intervertebral disc](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35800)
15. [Activation of hypoxia-inducible factor-1 in the rat cerebral cortex after transient global ischemia: potential role of insulin-like growth factor-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35800)
16. [Hepatic changes of erythropoietin gene expression in a rat model of acute-phase response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35800)
17. [Prolonged mechanical stretch is associated with upregulation of hypoxia-inducible factors and reduced contraction in rat inferior vena cava](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35800)
18. [Different protective actions of losartan and tempol on the renal inflammatory response to acute sodium overload](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35800)
19. [Myocardial infarction in diabetic rats: role of hyperglycaemia on infarct size and early expression of hypoxia-inducible factor 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35800)
20. [Hypoxia and hypoxia-inducible factor-1 target genes in central nervous system radiation injury: a role for vascular endothelial growth factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35800)
21. [Hypoxic stress-induced changes in adrenergic function: role of HIF1 alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35800)
22. [Stress induces transient auditory hypersensitivity in rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35800)
23. [HIF-1 alpha is an essential effector for purine nucleoside-mediated neuroprotection against hypoxia in PC12 cells and primary cerebellar granule neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35800)
24. [Exercise alters SIRT1, SIRT6, NAD and NAMPT levels in skeletal muscle of aged rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35800)
25. [Neuronal and glial alterations due to focal cortical hypoxia induced by direct cobalt chloride (CoCl2) brain injection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35800)
26. [The effect of 2-methoxyestradiol, a HIF-1 alpha inhibitor, in global cerebral ischemia in rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35800)
27. [Insulin activates hypoxia-inducible factor-1alpha in human and rat vascular smooth muscle cells via phosphatidylinositol-3 kinase and mitogen-activated protein kinase pathways: impairment in insulin resistance owing to defects in insulin signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35800)
28. [The effect of hypoxia-inducible factor 1-alpha on hypoxia-induced apoptosis in primary neonatal rat ventricular myocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35800)
29. [HIF-1 inhibition decreases systemic vascular remodelling diseases by promoting apoptosis through a hexokinase 2-dependent mechanism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35800)
30. [Chronic hypoxia- and monocrotaline-induced elevation of hypoxia-inducible factor-1 alpha levels and pulmonary hypertension](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35800)
31. [Down-regulation of hypoxia inducible factor-1alpha: a possible explanation for the protective effects of estrogen on genioglossus fatigue resistance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35800)
32. [HNF4α contributes to glucose formation in aged rat hepatocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35800)
33. [Mild hypoxia‐induced cardiomyocyte hypertrophy via up‐regulation of HIF‐1α‐mediated TRPC signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35800)
34. [Effects of RNAi on hypoxia inducible factor-1alpha activity and proliferation of hypoxic pulmonary artery smooth muscle cells in rat](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35800)
35. [Vulnerability of gastric mucosa to prednisolone in rats chronically exposed to cigarette smoke](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35800)
36. [Stretch-Induced Uterine Myocyte Differentiation During Rat Pregnancy: Involvement of Caspase Activation1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35800)
37. [Mitochondrial regulation by c-Myc and hypoxia-inducible factor-1 alpha controls sensitivity to econazole](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35800)
38. [An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35800)
39. [Ambivalent effects of compound C (dorsomorphin) on inflammatory response in LPS-stimulated rat primary microglial cultures](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35800)
40. [Rat carotid body chemosensory discharge and glomus cell HIF-1 alpha expression in vitro: regulation by a common oxygen sensor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35800)
41. [Sodium nitrite induces PC12 cell differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35800)
42. [Enhancement of glycolysis in cardiomyocytes elevates endothelin-1 expression through the transcriptional factor hypoxia-inducible factor-1 alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35800)
43. [Cyclic strain influences the expression of the vascular endothelial growth factor (VEGF) and the hypoxia inducible factor 1 alpha (HIF-1alpha) in tendon fibroblasts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35800)
44. [Glucose uptake and adenoviral mediated GLUT1 infection decrease hypoxia-induced HIF-1alpha levels in cardiac myocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35800)
45. [Recombinant human interleukin (IL)-1 beta-mediated regulation of hypoxia-inducible factor-1 alpha (HIF-1 alpha) stabilization, nuclear translocation and activation requires an antioxidant/reactive oxygen species (ROS)-sensitive mechanism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35800)
46. [Sphingosine-1-phosphate: a novel nonhypoxic activator of hypoxia-inducible factor-1 in vascular cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35800)
47. [Cardiac expressions of HIF-1 alpha and HLF/EPAS, two basic loop helix/PAS domain transcription factors involved in adaptative responses to hypoxic stresses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35800)
48. [Cardiac remodelling hinders activation of cyclooxygenase-2, diminishing protection by delayed pharmacological preconditioning: role of HIF1 alpha and CREB](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35800)
49. [Cyanide preconditioning protects brain endothelial and NT2 neuron-like cells against glucotoxicity: role of mitochondrial reactive oxygen species and HIF-1α](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35800)
50. [Ginkgolides mimic the effects of hypoxic preconditioning to protect C6 cells against ischemic injury by up-regulation of hypoxia-inducible factor-1 alpha and erythropoietin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35800)