# hypoxia inducible factor 1 subunit alpha

> mammalian protein found in Homo sapiens

**Wikidata**: [Q5629645](https://www.wikidata.org/wiki/Q5629645)  
**Source**: https://4ort.xyz/entity/hypoxia-inducible-factor-1-subunit-alpha-q5629645


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q16665)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665)
5. [Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665)
6. [Transcriptional activation of HIF-1 by RORalpha and its role in hypoxia signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665)
7. [Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665)
8. [Fructose-1,6-bisphosphatase opposes renal carcinoma progression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665)
9. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16665&geneProductId=UniProtKB:Q16665)
10. [Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665)
11. [FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665)
12. [Myeloid Translocation Gene-16 Co-Repressor Promotes Degradation of Hypoxia-Inducible Factor 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665)
13. [Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665)
14. [Ubiquitin-specific Protease 19 (USP19) Regulates Hypoxia-inducible Factor 1α (HIF-1α) during Hypoxia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665)
15. [In silico structural and functional characterization of the RSUME splice variants](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665)
16. [SIRT2 regulates tumour hypoxia response by promoting HIF-1α hydroxylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665)
17. [Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665)
18. [Regulation of the VHL/HIF-1 pathway by DJ-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665)
19. [SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665)
20. [HIF1α deubiquitination by USP8 is essential for ciliogenesis in normoxia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665)
21. [The peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665)
22. [MSF-A interacts with hypoxia-inducible factor-1alpha and augments hypoxia-inducible factor transcriptional activation to affect tumorigenicity and angiogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665)
23. [Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665)
24. [Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665)
25. [Cbx4 Governs HIF-1α to Potentiate Angiogenesis of Hepatocellular Carcinoma by Its SUMO E3 Ligase Activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665)
26. [β-arrestin1 mediates metastatic growth of breast cancer cells by facilitating HIF-1-dependent VEGF expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665)
27. [MiR-1 suppresses tumor cell proliferation in colorectal cancer by inhibition of Smad3-mediated tumor glycolysis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665)
28. [Notch signaling mediates hypoxia-induced tumor cell migration and invasion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665)
29. [The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665)
30. [E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665)
31. [NEDD8 acts as a 'molecular switch' defining the functional selectivity of VHL](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665)
32. [The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665)
33. [Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665)
34. [Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665)
35. [Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665)
36. [Histone deacetylase inhibitors repress the transactivation potential of hypoxia-inducible factors independently of direct acetylation of HIF-alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665)
37. [RKTG inhibits angiogenesis by suppressing MAPK-mediated autocrine VEGF signaling and is downregulated in clear-cell renal cell carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665)
38. [Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665)
39. [Involvement of estrogen-related receptors in transcriptional response to hypoxia and growth of solid tumors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665)
40. [Modulation of p300 binding by posttranslational modifications of the C-terminal activation domain of hypoxia-inducible factor-1alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665)
41. [Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665)
42. [UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665)
43. [Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665)
44. [Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665)
45. [MicroRNA-566 activates EGFR signaling and its inhibition sensitizes glioblastoma cells to nimotuzumab](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665)
46. [Metastasis-associated protein 1 enhances stability of hypoxia-inducible factor-1alpha protein by recruiting histone deacetylase 1.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665)
47. [PIASy stimulates HIF1α SUMOylation and negatively regulates HIF1α activity in response to hypoxia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665)
48. [EAF2 Suppresses Hypoxia-Induced Factor 1α Transcriptional Activity by Disrupting Its Interaction with Coactivator CBP/p300](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665)
49. [Network organization of the human autophagy system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665)
50. [SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16665)