# Hypoxia inducible factor 1, alpha subunit

> mammalian protein found in Mus musculus

**Wikidata**: [Q21981069](https://www.wikidata.org/wiki/Q21981069)  
**Source**: https://4ort.xyz/entity/hypoxia-inducible-factor-1-alpha-subunit


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q61221)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221)
5. [Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221)
6. [Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221)
7. [The survival effect of mitochondrial Higd-1a is associated with suppression of cytochrome C release and prevention of caspase activation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61221&geneProductId=UniProtKB:Q61221)
8. [Transcriptional activation of hypoxia-inducible factor-1alpha by HDAC4 and HDAC5 involves differential recruitment of p300 and FIH-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221)
9. [Pro-apoptotic activity of inhibitory PAS domain protein (IPAS), a negative regulator of HIF-1, through binding to pro-survival Bcl-2 family proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221)
10. [Induction of phosphoglycerate kinase 1 gene expression by hypoxia. Roles of Arnt and HIF1alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221)
11. [Increased activity of hypoxia-inducible factor 1 is associated with early embryonic lethality in Commd1 null mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221)
12. [Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221)
13. [Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221)
14. [Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221)
15. [HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221)
16. [A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221)
17. [Structural integration in hypoxia-inducible factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221)
18. [Molecular characterization of the murine Hif-1 alpha locus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221)
19. [Advanced Glycated End-Products Affect HIF-Transcriptional Activity in Renal Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221)
20. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61221&geneProductId=UniProtKB:Q61221)
21. [The hypoxia-inducible microRNA cluster miR-199a∼214 targets myocardial PPARδ and impairs mitochondrial fatty acid oxidation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221)
22. [Advanced Glycated End-Products Affect HIF-Transcriptional Activity in Renal Cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61221&geneProductId=UniProtKB:Q61221)
23. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61221&geneProductId=UniProtKB:Q61221)
24. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221)
25. [The survival effect of mitochondrial Higd-1a is associated with suppression of cytochrome C release and prevention of caspase activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221)
26. [Pro-apoptotic activity of inhibitory PAS domain protein (IPAS), a negative regulator of HIF-1, through binding to pro-survival Bcl-2 family proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61221&geneProductId=UniProtKB:Q61221)
27. [Metallothionein-III induces HIF-1alpha-mediated VEGF expression in brain endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61221&geneProductId=UniProtKB:Q61221)
28. [Loss of PINK1 attenuates HIF-1α induction by preventing 4E-BP1-dependent switch in protein translation under hypoxia](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61221&geneProductId=UniProtKB:Q61221)
29. [Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61221&geneProductId=UniProtKB:Q61221)
30. [Superoxide dismutase-3 promotes full expression of the EPO response to hypoxia](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61221&geneProductId=UniProtKB:Q61221)
31. [RSUME is implicated in HIF-1-induced VEGF-A production in pituitary tumour cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61221&geneProductId=UniProtKB:Q61221)
32. [Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61221&geneProductId=UniProtKB:Q61221)
33. [Hypoxia in cartilage: HIF-1α is essential for chondrocyte growth arrest and survival](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61221&geneProductId=UniProtKB:Q61221)
34. [Isoform-specific expression of hypoxia-inducible factor-1alpha during the late stages of mouse spermiogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221)
35. [Metallothionein-III induces HIF-1alpha-mediated VEGF expression in brain endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221)
36. [Loss of PINK1 attenuates HIF-1α induction by preventing 4E-BP1-dependent switch in protein translation under hypoxia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221)
37. [RSUME is implicated in HIF-1-induced VEGF-A production in pituitary tumour cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221)
38. [Superoxide dismutase-3 promotes full expression of the EPO response to hypoxia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221)
39. [Hypoxia in cartilage: HIF-1α is essential for chondrocyte growth arrest and survival](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221)
40. [Defective brain development in mice lacking the Hif-1alpha gene in neural cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221)
41. [Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1alpha -deficient chimeric mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221)
42. [Loss of skeletal muscle HIF-1alpha results in altered exercise endurance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221)
43. [Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1α](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221)
44. [Hypoxia-inducible Factor-1α Protein Negatively Regulates Load-induced Bone Formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221)
45. [Cardia bifida, defective heart development and abnormal neural crest migration in embryos lacking hypoxia-inducible factor-1alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221)
46. [Loss of hepatocyte-nuclear-factor-1alpha impacts on adult mouse intestinal epithelial cell growth and cell lineages differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221)
47. [Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221)
48. [VEGFA is necessary for chondrocyte survival during bone development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221)
49. [Defective vascularization of HIF-1alpha-null embryos is not associated with VEGF deficiency but with mesenchymal cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221)
50. [Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61221)