Hypocretin receptor 2
type: Thing
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P129
  value: almorexant
additional property: PropertyValue
  property ID: P129
  value: EMPA
additional property: PropertyValue
  property ID: P129
  value: filorexant
additional property: PropertyValue
  property ID: P352
  value: O43614
additional property: PropertyValue
  property ID: P361
  value: Orexin receptor 2
additional property: PropertyValue
  property ID: P361
  value: GPCR, rhodopsin-like, 7TM, protein family
additional property: PropertyValue
  property ID: P527
  value: GPCR, rhodopsin-like, 7TM
additional property: PropertyValue
  property ID: P637
  value: NP_001517
additional property: PropertyValue
  property ID: P637
  value: XP_016866287
additional property: PropertyValue
  property ID: P638
  value: 4S0V
additional property: PropertyValue
  property ID: P680
  value: peptide hormone binding
additional property: PropertyValue
  property ID: P680
  value: peptide binding
additional property: PropertyValue
  property ID: P680
  value: G protein-coupled receptor activity
additional property: PropertyValue
  property ID: P681
  value: integral component of membrane
additional property: PropertyValue
  property ID: P681
  value: plasma membrane
additional property: PropertyValue
  property ID: P681
  value: membrane
additional property: PropertyValue
  property ID: P682
  value: phospholipase C-activating G protein-coupled receptor signaling pathway
additional property: PropertyValue
  property ID: P682
  value: cellular response to hormone stimulus
additional property: PropertyValue
  property ID: P682
  value: regulation of circadian sleep/wake cycle, sleep
additional property: PropertyValue
  property ID: P702
  value: HCRTR2
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000359899
additional property: PropertyValue
  property ID: P705
  value: ENSP00000477548
confidence:
  popularity graph score:
    score: 0.002
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 15
      unique citations norm: 0.006
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 15
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P129:
    value: Q4355941
    source count: 1
    confidence: 0.2
    value label: almorexant
  P129:
    value: Q5323607
    source count: 1
    confidence: 0.2
    value label: EMPA
  P129:
    value: Q18355303
    source count: 1
    confidence: 0.2
    value label: filorexant
  P129:
    value: Q7388911
    source count: 1
    confidence: 0.2
    value label: SB-334867
  P129:
    value: Q7388914
    source count: 1
    confidence: 0.2
    value label: SB-649868
  P352:
    value: O43614
    source count: 1
    confidence: 0.2
  P361:
    value: Q24720433
    source count: 1
    confidence: 0.2
    value label: Orexin receptor 2
  P361:
    value: Q83162561
    source count: 1
    confidence: 0.2
    value label: GPCR, rhodopsin-like, 7TM, protein family
  P527:
    value: Q24781798
    source count: 1
    confidence: 0.2
    value label: GPCR, rhodopsin-like, 7TM
  P637:
    value: NP_001517
    source count: 1
    confidence: 0.2
  P637:
    value: XP_016866287
    source count: 1
    confidence: 0.2
  P638:
    value: 4S0V
    source count: 1
    confidence: 0.2
  P680:
    value: Q14875276
    source count: 1
    confidence: 0.2
    value label: peptide hormone binding
  P680:
    value: Q14633870
    source count: 1
    confidence: 0.2
    value label: peptide binding
  P680:
    value: Q14859545
    source count: 3
    confidence: 0.6
    value label: G protein-coupled receptor activity
  P680:
    value: Q14820643
    source count: 1
    confidence: 0.2
    value label: signal transducer activity
  P680:
    value: Q21113343
    source count: 1
    confidence: 0.2
    value label: neuropeptide receptor activity
  P681:
    value: Q14327652
    source count: 2
    confidence: 0.4
    value label: integral component of membrane
  P681:
    value: Q29548
    source count: 2
    confidence: 0.4
    value label: plasma membrane
  P681:
    value: Q14349455
    source count: 1
    confidence: 0.2
    value label: membrane
  P681:
    value: Q14859540
    source count: 2
    confidence: 0.4
    value label: integral component of plasma membrane
  P681:
    value: Q14859540
    source count: 3
    confidence: 0.6
    value label: integral component of plasma membrane

value: Q14859603
source count: 1
confidence: 0.2
value label: phospholipase C-activating G protein-coupled receptor signaling pathway

value: Q14864711
source count: 1
confidence: 0.2
value label: cellular response to hormone stimulus

value: Q14864084
source count: 1
confidence: 0.2
value label: regulation of circadian sleep/wake cycle, sleep

value: Q21122434
source count: 1
confidence: 0.2
value label: circadian sleep/wake cycle process

value: Q828130
source count: 1
confidence: 0.2
value label: signal transduction

value: Q18026854
source count: 1
confidence: 0.2
value label: HCRTR2

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000359899
source count: 1
confidence: 0.2

value: ENSP00000477548
source count: 1
confidence: 0.2

source: Open Targets Platform
stated in qid: Q113138000
retrieved: 2023-08-14

source: Open Targets Platform
stated in qid: Q113138000
retrieved: 2023-08-14

source: Open Targets Platform
stated in qid: Q113138000
retrieved: 2023-08-14

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: GOA
stated in qid: Q28018111
retrieved: 2018-06-05

source: Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
stated in qid: Q24315738
retrieved: 2019-04-08

source: Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors
stated in qid: Q27704228
retrieved: 2018-06-05

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-04-08

source: Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors
stated in qid: Q27704228
retrieved: 2019-04-08

source: Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
stated in qid: Q24315738
retrieved: 2018-06-05

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2019-11-13

source: IUPHAR/BPS Guide to PHARMACOLOGY
stated in qid: Q17091219
retrieved: 2016-08-17

source: Q20641742
stated in qid: Q20641742
retrieved: 2020-05-30

source: Ensembl Release 99
stated in qid: Q83867711

wikidata id: Q21122435
domain: protein
level: standard
html url: https://4ort.xyz/entity/hypocretin-receptor-2
markdown url: https://4ort.xyz/entity/hypocretin-receptor-2.md
facts url summary: https://4ort.xyz/entity/hypocretin-receptor-2/facts.json
facts url standard: https://4ort.xyz/entity/hypocretin-receptor-2/facts.json
facts url full: https://4ort.xyz/entity/hypocretin-receptor-2/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-31T12:00:44.700951Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T13:58:50.900290+00:00Z