# Hyaluronidase 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21103082](https://www.wikidata.org/wiki/Q21103082)  
**Source**: https://4ort.xyz/entity/hyaluronidase-2


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q12891)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12891&geneProductId=UniProtKB:Q12891)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891)
6. [Ultraviolet‐B Irradiation Induces Differential Regulations of Hyaluronidase Expression and Activity in Normal Human Keratinocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891)
7. [Amino acid residues that are important for Hyal2 function as a receptor for jaagsiekte sheep retrovirus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891)
8. [Expression and cellular localization of human hyaluronidase-2 in articular chondrocytes and cultured cell lines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891)
9. [Hyaluronidases and CD44 undergo differential modulation during chondrogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891)
10. [HYAL2, a human gene expressed in many cells, encodes a lysosomal hyaluronidase with a novel type of specificity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891)
11. [Platelet-derived hyaluronidase 2 cleaves hyaluronan into fragments that trigger monocyte-mediated production of proinflammatory cytokines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891)
12. [Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891)
13. [Reactive oxygen species and hyaluronidase 2 regulate airway epithelial hyaluronan fragmentation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891)
14. [CD44-dependent intracellular and extracellular catabolism of hyaluronic acid by hyaluronidase-1 and -2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891)
15. [Hyaluronidase expression and activity is regulated by pro-inflammatory cytokines in human airway epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891)
16. [Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891)
17. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891)
18. [Transforming growth factor beta1 signaling via interaction with cell surface Hyal-2 and recruitment of WWOX/WOX1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891)
19. [Hyal2 is a glycosylphosphatidylinositol-anchored, lipid raft-associated hyaluronidase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891)
20. [bFGF induces changes in hyaluronan synthase and hyaluronidase isoform expression and modulates the migration capacity of fibrosarcoma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891)
21. [HYAL1 and HYAL2 inhibit tumour growth in vivo but not in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12891)
22. Ensembl Release 99
23. [Identifiers.org](https://registry.identifiers.org/registry/uniprot)