# Hyaluronidase 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21118410](https://www.wikidata.org/wiki/Q21118410)  
**Source**: https://4ort.xyz/entity/hyaluronidase-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q12794)
3. Q20641742
4. [Epigenetic regulation of HYAL-1 hyaluronidase expression. identification of HYAL-1 promoter](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794)
6. [Upregulation of HYAL1 Expression in Breast Cancer Promoted Tumor Cell Proliferation, Migration, Invasion and Angiogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12794&geneProductId=UniProtKB:Q12794)
8. [Endocytosis of hyaluronidase-1 by the liver](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12794&geneProductId=UniProtKB:Q12794)
9. [Upregulation of HYAL1 Expression in Breast Cancer Promoted Tumor Cell Proliferation, Migration, Invasion and Angiogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12794&geneProductId=UniProtKB:Q12794)
10. [Hyaluronidase expression and activity is regulated by pro-inflammatory cytokines in human airway epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12794&geneProductId=UniProtKB:Q12794)
11. [Hyaluronidases and CD44 undergo differential modulation during chondrogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12794&geneProductId=UniProtKB:Q12794)
12. [HYAL1 overexpression is correlated with the malignant behavior of human breast cancer](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12794&geneProductId=UniProtKB:Q12794)
13. [Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12794&geneProductId=UniProtKB:Q12794)
14. [Ultraviolet‐B Irradiation Induces Differential Regulations of Hyaluronidase Expression and Activity in Normal Human Keratinocytes](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12794&geneProductId=UniProtKB:Q12794)
15. [Purification, Cloning, and Expression of Human Plasma Hyaluronidase](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12794&geneProductId=UniProtKB:Q12794)
16. [Designed human serum hyaluronidase 1 variant, HYAL1DeltaL, exhibits activity up to pH 5.9](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12794&geneProductId=UniProtKB:Q12794)
17. [Subtype specific elevated expression of hyaluronidase-1 (HYAL-1) in epithelial ovarian cancer](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12794&geneProductId=UniProtKB:Q12794)
18. [CD44-dependent intracellular and extracellular catabolism of hyaluronic acid by hyaluronidase-1 and -2](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12794&geneProductId=UniProtKB:Q12794)
19. [Ultraviolet‐B Irradiation Induces Differential Regulations of Hyaluronidase Expression and Activity in Normal Human Keratinocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794)
20. [Hyaluronidases and CD44 undergo differential modulation during chondrogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794)
21. [Endocytosis of hyaluronidase-1 by the liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794)
22. [Purification, Cloning, and Expression of Human Plasma Hyaluronidase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794)
23. [Subtype specific elevated expression of hyaluronidase-1 (HYAL-1) in epithelial ovarian cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794)
24. [HYAL1 overexpression is correlated with the malignant behavior of human breast cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794)
25. [Designed human serum hyaluronidase 1 variant, HYAL1DeltaL, exhibits activity up to pH 5.9](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794)
26. [CD44-dependent intracellular and extracellular catabolism of hyaluronic acid by hyaluronidase-1 and -2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794)
27. [Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794)
28. [Hyaluronidase expression and activity is regulated by pro-inflammatory cytokines in human airway epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794)
29. [Characterization of hyaluronan cable structure and function in renal proximal tubular epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794)
30. [Expression and cellular localization of human hyaluronidase-2 in articular chondrocytes and cultured cell lines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794)
31. [Proteomic analysis of podocyte exosome-enriched fraction from normal human urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12794&geneProductId=UniProtKB:Q12794)
32. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12794&geneProductId=UniProtKB:Q12794)
33. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794)
34. [Reactive oxygen species and hyaluronidase 2 regulate airway epithelial hyaluronan fragmentation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794)
35. [Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794)
36. [bFGF induces changes in hyaluronan synthase and hyaluronidase isoform expression and modulates the migration capacity of fibrosarcoma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794)
37. [HYAL1 and HYAL2 inhibit tumour growth in vivo but not in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12794)
38. Ensembl Release 99