# Huntingtin interacting protein 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21111483](https://www.wikidata.org/wiki/Q21111483)  
**Source**: https://4ort.xyz/entity/huntingtin-interacting-protein-1-q21111483


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O00291)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O00291&geneProductId=UniProtKB:O00291)
5. [HIP1 and HIP1r stabilize receptor tyrosine kinases and bind 3-phosphoinositides via epsin N-terminal homology domains](http://www.ebi.ac.uk/QuickGO/annotations?protein=O00291&geneProductId=UniProtKB:O00291)
6. [Clathrin- and AP-2-binding sites in HIP1 uncover a general assembly role for endocytic accessory proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=O00291&geneProductId=UniProtKB:O00291)
7. [HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291)
8. [Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291)
9. [HIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light chain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291)
10. [Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291)
11. [Huntingtin-interacting protein 1-mediated neuronal cell death occurs through intrinsic apoptotic pathways and mitochondrial alterations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291)
12. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291)
13. [A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291)
14. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291)
15. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291)
16. [Replacement of charged and polar residues in the coiled‐coiled interface of huntingtin‐interacting protein 1 (HIP1) causes aggregation and cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291)
17. [Huntingtin interacting proteins are genetic modifiers of neurodegeneration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291)
18. [The NECAP PHear domain increases clathrin accessory protein binding potential](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291)
19. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291)
20. [The Sla2p/HIP1/HIP1R family: similar structure, similar function in endocytosis?](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291)
21. [HIP1 and HIP1r stabilize receptor tyrosine kinases and bind 3-phosphoinositides via epsin N-terminal homology domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291)
22. [Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain](http://www.ebi.ac.uk/QuickGO/annotations?protein=O00291&geneProductId=UniProtKB:O00291)
23. [Huntingtin-interacting protein 1 (Hip1) and Hip1-related protein (Hip1R) bind the conserved sequence of clathrin light chains and thereby influence clathrin assembly in vitro and actin distribution in vivo](http://www.ebi.ac.uk/QuickGO/annotations?protein=O00291&geneProductId=UniProtKB:O00291)
24. [Huntingtin-interacting protein 1 (Hip1) and Hip1-related protein (Hip1R) bind the conserved sequence of clathrin light chains and thereby influence clathrin assembly in vitro and actin distribution in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291)
25. [Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291)
26. [Clathrin- and AP-2-binding sites in HIP1 uncover a general assembly role for endocytic accessory proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291)
27. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291)
28. [HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain](http://www.ebi.ac.uk/QuickGO/annotations?protein=O00291&geneProductId=UniProtKB:O00291)
29. [Huntingtin interacting protein 1 Is a clathrin coat binding protein required for differentiation of late spermatogenic progenitors](http://www.ebi.ac.uk/QuickGO/annotations?protein=O00291&geneProductId=UniProtKB:O00291)
30. [HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291)
31. [HIP1 functions in clathrin-mediated endocytosis through binding to clathrin and adaptor protein 2](http://www.ebi.ac.uk/QuickGO/annotations?protein=O00291&geneProductId=UniProtKB:O00291)
32. [The Sla2p/HIP1/HIP1R family: similar structure, similar function in endocytosis?](http://www.ebi.ac.uk/QuickGO/annotations?protein=O00291&geneProductId=UniProtKB:O00291)
33. [Huntingtin interacting protein 1 Is a clathrin coat binding protein required for differentiation of late spermatogenic progenitors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291)
34. [HIP1 functions in clathrin-mediated endocytosis through binding to clathrin and adaptor protein 2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291)
35. [The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=O00291&geneProductId=UniProtKB:O00291)
36. [HIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light chain](http://www.ebi.ac.uk/QuickGO/annotations?protein=O00291&geneProductId=UniProtKB:O00291)
37. [Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291)
38. [Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi](http://www.ebi.ac.uk/QuickGO/annotations?protein=O00291&geneProductId=UniProtKB:O00291)
39. [The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00291)
40. Ensembl Release 99