# HtrA serine peptidase 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21111681](https://www.wikidata.org/wiki/Q21111681)  
**Source**: https://4ort.xyz/entity/htra-serine-peptidase-2-q21111681


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O43464)
3. Q20641742
4. [Characterization of a novel human serine protease that has extensive homology to bacterial heat shock endoprotease HtrA and is regulated by kidney ischemia](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464)
5. [Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464)
6. [THAP5 is a human cardiac-specific inhibitor of cell cycle that is cleaved by the proapoptotic Omi/HtrA2 protease during cell death](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464)
7. [The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464)
8. [The protease Omi regulates mitochondrial biogenesis through the GSK3β/PGC-1α pathway](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464)
9. [HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464)
10. [The mitochondrial serine protease HtrA2/Omi cleaves RIP1 during apoptosis of Ba/F3 cells induced by growth factor withdrawal](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464)
11. [Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464)
12. [SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP)](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464)
13. [Dual regulatory switch confers tighter control on HtrA2 proteolytic activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464)
14. [A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464)
15. [GRIM-19 associates with the serine protease HtrA2 for promoting cell death](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464)
16. [No death without life: vital functions of apoptotic effectors](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464)
17. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464)
18. [Expression, purification, and functional analysis of the human serine protease HtrA2](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464)
19. [Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464)
20. [Inactivation of Omi/HtrA2 protease leads to the deregulation of mitochondrial Mulan E3 ubiquitin ligase and increased mitophagy](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464)
21. [Proteome-wide Identification of HtrA2/Omi Substrates](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464)
22. [PARK13 regulates PINK1 and subcellular relocation patterns under oxidative stress in neurons](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464)
23. [Tim50, a component of the mitochondrial translocator, regulates mitochondrial integrity and cell death](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464)
24. [Tissue-specific splicing of Omi stress-regulated endoprotease leads to an inactive protease with a modified PDZ motif](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464)
25. [High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464)
26. [Oxidative Stress-Induced Signaling Pathways Implicated in the Pathogenesis of Parkinson’s Disease](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464)
27. [Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43464&geneProductId=UniProtKB:O43464)
28. Ensembl Release 99
29. UMLS 2023