# HRas proto-oncogene, GTPase

> mammalian protein found in Homo sapiens

**Wikidata**: [Q5635781](https://www.wikidata.org/wiki/Q5635781)  
**Source**: https://4ort.xyz/entity/hras-proto-oncogene-gtpase


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL23293)
4. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P01112)
5. Q20641742
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112)
7. [The Ras-RasGAP Complex: Structural Basis for GTPase Activation and Its Loss in Oncogenic Ras Mutants](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112)
8. [Alternative splicing of the human proto-oncogene c-H-ras renders a new Ras family protein that trafficks to cytoplasm and nucleus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112)
9. [Nedd4 regulates ubiquitination and stability of the guanine-nucleotide exchange factor CNrasGEF](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112)
10. [RA-GEF, a novel Rap1A guanine nucleotide exchange factor containing a Ras/Rap1A-associating domain, is conserved between nematode and humans](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112)
11. [Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112)
12. [Modulation of guanine nucleotides bound to Ras in NIH3T3 cells by oncogenes, growth factors, and the GTPase activating protein (GAP)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112)
13. [p37δ is a new isoform of PI3K p110δ that increases cell proliferation and is overexpressed in tumors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112)
14. [The complex of Arl2-GTP and PDE delta: from structure to function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112)
15. [Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112)
16. [Transformation Efficiency of RasQ61 Mutants Linked to Structural Features of the Switch Regions in the Presence of Raf](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112)
17. [Prenylated Rab acceptor protein is a receptor for prenylated small GTPases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112)
18. [Identification of a novel Rac1-interacting protein involved in membrane ruffling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112)
19. [Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112)
20. [The RAS-Binding Domain of Human BRAF Protein Serine/Threonine Kinase Exhibits Allosteric Conformational Changes upon Binding HRAS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112)
21. [Protein binding and signaling properties of RIN1 suggest a unique effector function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112)
22. [Allosteric effects of the oncogenic RasQ61L mutant on Raf-RBD](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112)
23. [Ras membrane orientation and nanodomain localization generate isoform diversity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112)
24. [A human MAP kinase interactome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112)
25. [The RAP1 guanine nucleotide exchange factor Epac2 couples cyclic AMP and Ras signals at the plasma membrane](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112)
26. [Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112)
27. [Catalytic competence of the Ras-GEF domain of hSos1 requires intra-REM domain interactions mediated by phenylalanine 577](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112)
28. [Integrated RAS signaling defined by parallel NMR detection of effectors and regulators.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112)
29. [Nilotinib and MEK inhibitors induce synthetic lethality through paradoxical activation of RAF in drug-resistant chronic myeloid leukemia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112)
30. [Differences in flexibility underlie functional differences in the Ras activators son of sevenless and Ras guanine nucleotide releasing factor 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112)
31. [Regulation of growth and survival of activated T cells by cell-transducing inhibitors of Ras](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112)
32. [Regulation of Sos Activity by Intramolecular Interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112)
33. [Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112)
34. [Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112)
35. [Nucleocytoplasmic transport of Alp7/TACC organizes spatiotemporal microtubule formation in fission yeast](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112)
36. [RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112)
37. [The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112)
38. [Allosteric gating of Son of sevenless activity by the histone domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112)
39. [Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112)
40. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112)
41. [Protein interaction switches coordinate Raf-1 and MST2/Hippo signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112)
42. [The structural basis of the activation of Ras by Sos](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112)
43. [Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112)
44. [Reassessment of the role of FKBP38 in the Rheb/mTORC1 pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112)
45. [Novel type of Ras effector interaction established between tumour suppressor NORE1A and Ras switch II](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112)
46. [Structural analysis of autoinhibition in the Ras activator Son of sevenless](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112)
47. [A novel switch region regulates H-ras membrane orientation and signal output](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112)
48. [Identification of Nore1 as a potential Ras effector](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112)
49. [Genetic and functional characterization of putative Ras/Raf interaction inhibitors in C. elegans and mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112)
50. [Membrane-dependent signal integration by the Ras activator Son of sevenless](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01112)