# Host cell factor C1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21130029](https://www.wikidata.org/wiki/Q21130029)  
**Source**: https://4ort.xyz/entity/host-cell-factor-c1-q21130029


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P51610)
3. Q20641742
4. [The VP16 accessory protein HCF is a family of polypeptides processed from a large precursor protein](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51610&geneProductId=UniProtKB:P51610)
5. [The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51610)
6. [Mixed Lineage Leukemia 5 (MLL5) Protein Regulates Cell Cycle Progression and E2F1-responsive Gene Expression via Association with Host Cell Factor-1 (HCF-1)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51610)
7. [Crosstalk between O-GlcNAcylation and proteolytic cleavage regulates the host cell factor-1 maturation pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51610)
8. [Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51610)
9. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51610&geneProductId=UniProtKB:P51610)
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51610)
11. [Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51610)
12. [The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51610)
13. [Luman, a New Member of the CREB/ATF Family, Binds to Herpes Simplex Virus VP16-Associated Host Cellular Factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51610)
14. [Host cell factor-1 interacts with and antagonizes transactivation by the cell cycle regulatory factor Miz-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51610)
15. [Mutations in host cell factor 1 separate its role in cell proliferation from recruitment of VP16 and LZIP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51610)
16. [PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51610)
17. [TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51610)
18. [Association of C-terminal ubiquitin hydrolase BRCA1-associated protein 1 with cell cycle regulator host cell factor 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51610)
19. [Zhangfei: a second cellular protein interacts with herpes simplex virus accessory factor HCF in a manner similar to Luman and VP16.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51610)
20. [HCF-1 functions as a coactivator for the zinc finger protein Krox20](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51610)
21. [Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51610)
22. [A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51610)
23. [Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51610)
24. [The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51610)
25. [Ronin is essential for embryogenesis and the pluripotency of mouse embryonic stem cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51610)
26. [A novel protein, Luman/CREB3 recruitment factor, inhibits Luman activation of the unfolded protein response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51610)
27. [Defining the human deubiquitinating enzyme interaction landscape](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51610)
28. [A High-Density Map for Navigating the Human Polycomb Complexome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51610)
29. [Zhangfei is a potent and specific inhibitor of the host cell factor-binding transcription factor Luman](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51610)
30. [SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51610)
31. [O-GlcNAc transferase catalyzes site-specific proteolysis of HCF-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51610)
32. [BAP1 is phosphorylated at serine 592 in S-phase following DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51610)
33. [E-cadherin interactome complexity and robustness resolved by quantitative proteomics](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51610&geneProductId=UniProtKB:P51610)
34. [E-cadherin interactome complexity and robustness resolved by quantitative proteomics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51610)
35. [Potential role for luman, the cellular homologue of herpes simplex virus VP16 (alpha gene trans-inducing factor), in herpesvirus latency](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51610)
36. [Cell death of chondrocytes is a combination between apoptosis and autophagy during the pathogenesis of Osteoarthritis within an experimental model](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51610)
37. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51610&geneProductId=UniProtKB:P51610)
38. [Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51610)
39. [Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51610&geneProductId=UniProtKB:P51610)
40. [Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51610&geneProductId=UniProtKB:P51610)
41. [Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51610&geneProductId=UniProtKB:P51610)
42. [The cellular C1 factor of the herpes simplex virus enhancer complex is a family of polypeptides](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51610)
43. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51610)
44. [Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51610)
45. Ensembl Release 99
46. UMLS 2023