# homeostatic iron regulator

> mammalian protein found in Homo sapiens

**Wikidata**: [Q426648](https://www.wikidata.org/wiki/Q426648)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/HFE_(gene))  
**Source**: https://4ort.xyz/entity/homeostatic-iron-regulator


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q30201)
3. Q20641742
4. [A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201)
5. [Crystal Structure of the Hemochromatosis Protein HFE and Characterization of Its Interaction with Transferrin Receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201)
6. [The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201)
7. [Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201)
8. [The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201)
9. [Transferrin receptor co-localizes and interacts with the hemochromatosis factor (HFE) and the divalent metal transporter-1 (DMT1) in trophoblast cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201)
10. [The Q283P amino-acid change in HFE leads to structural and functional consequences similar to those described for the mutated 282Y HFE protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201)
11. [N-glycosylation is important for the correct intracellular localization of HFE and its ability to decrease cell surface transferrin binding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201)
12. [Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201)
13. [The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201)
14. [Crystal Structure of the Hemochromatosis Protein HFE and Characterization of Its Interaction with Transferrin Receptor](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201)
15. [The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201)
16. [HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201)
17. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201)
18. [Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201)
19. [HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201)
20. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201)
21. [HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201)
22. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201)
23. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201)
24. [Co-localization of the mammalian hemochromatosis gene product (HFE) and a newly identified transferrin receptor (TfR2) in intestinal tissue and cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201)
25. [Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201)
26. [HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201)
27. [A time course of hepcidin response to iron challenge in patients with HFE and TFR2 hemochromatosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201)
28. [A time course of hepcidin response to iron challenge in patients with HFE and TFR2 hemochromatosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201)
29. [The WT hemochromatosis protein HFE inhibits CD8+ T‐lymphocyte activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201)
30. [The hereditary hemochromatosis protein, HFE, specifically regulates transferrin-mediated iron uptake in HeLa cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q30201&geneProductId=UniProtKB:Q30201)
31. [The hereditary hemochromatosis protein, HFE, specifically regulates transferrin-mediated iron uptake in HeLa cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q30201)
32. Ensembl Release 99
33. Identifiers.org