Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific
type: Thing
description: mouse protein (annotated by UniProtKB/Swiss-Prot O88491)
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P352
  value: O88491
additional property: PropertyValue
  property ID: P361
  value: Zinc finger, FYVE/PHD-type
additional property: PropertyValue
  property ID: P361
  value: Zinc finger, RING/FYVE/PHD-type
additional property: PropertyValue
  property ID: P361
  value: Zinc finger, PHD-finger, protein family
additional property: PropertyValue
  property ID: P527
  value: Zinc finger, PHD-type, conserved site
additional property: PropertyValue
  property ID: P527
  value: Post-SET domain
additional property: PropertyValue
  property ID: P527
  value: SET domain
additional property: PropertyValue
  property ID: P638
  value: 2NAA
additional property: PropertyValue
  property ID: P680
  value: metal ion binding
additional property: PropertyValue
  property ID: P680
  value: transcription corepressor activity
additional property: PropertyValue
  property ID: P680
  value: transferase activity
additional property: PropertyValue
  property ID: P681
  value: histone methyltransferase complex
additional property: PropertyValue
  property ID: P681
  value: chromosome
additional property: PropertyValue
  property ID: P681
  value: nucleus
additional property: PropertyValue
  property ID: P682
  value: regulation of histone H3-K36 methylation
additional property: PropertyValue
  property ID: P682
  value: histone methylation
additional property: PropertyValue
  property ID: P682
  value: gastrulation with mouth forming second
additional property: PropertyValue
  property ID: P702
  value: Nsd1
additional property: PropertyValue
  property ID: P703
  value: house mouse
confidence:
  popularity graph score:
    score: 0.002
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 15
      unique citations norm: 0.006
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 15
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 0
    confidence: 0.0
    value label: protein
  P352:
    value: O88491
    source count: 1
    confidence: 0.2
  P361:
    value: Q24719950
    source count: 1
    confidence: 0.2
    value label: Zinc finger, FYVE/PHD-type
  P361:
    value: Q24786519
    source count: 1
    confidence: 0.2
    value label: Zinc finger, RING/FYVE/PHD-type
  P361:
    value: Q83137204
    source count: 1
    confidence: 0.2
    value label: Zinc finger, PHD-finger, protein family
  P361:
    value: Q83146471
    source count: 1
    confidence: 0.2
    value label: Zinc finger, PHD-type, protein family
  P361:
    value: Q83140138
    source count: 1
    confidence: 0.2
    value label: Post-SET domain, protein family
  P527:
    value: Q24775106
    source count: 1
    confidence: 0.2
    value label: Zinc finger, PHD-type, conserved site
  P527:
    value: Q24770698
    source count: 1
    confidence: 0.2
    value label: Post-SET domain
  P527:
    value: Q24770667
    source count: 1
    confidence: 0.2
    value label: SET domain
  P527:
    value: Q24727292
    source count: 1
    confidence: 0.2
    value label: AWS domain
  P527:
    value: Q24788168
    source count: 1
    confidence: 0.2
    value label: Zinc finger, RING-type
  P638:
    value: 2NAA
    source count: 1
    confidence: 0.2
  P680:
    value: Q13667380
    source count: 1
    confidence: 0.2
    value label: metal ion binding
  P680:
    value: Q14864664
    source count: 1
    confidence: 0.2
    value label: transcription corepressor activity
  P680:
    value: Q14840131
    source count: 1
    confidence: 0.2
    value label: transferase activity
  P680:
    value: Q21102236
    source count: 1
    confidence: 0.2
    value label: histone methyltransferase activity (H4-K20 specific)
  P680:
    value: Q14914593
    source count: 1
    confidence: 0.2
    value label: thyroid hormone receptor binding
  P681:
    value: Q14913027
    source count: 1
    confidence: 0.2
    value label: histone methyltransferase complex
  P681:
    value: Q37748
    source count: 1
    confidence: 0.2
    value label: chromosome
  P681:
    value: Q40260
    source count: 4
    confidence: 0.8
    value label: nucleus
  P681:
    value: Q180951
    source count: 1
    confidence: 0.2
    value label: chromatin
  P681:
    value: Q40260
    source count: 5
    confidence: 1.0
    value label: nucleus
  P682:
    value: Q21121753
    source count: 1
    confidence: 0.2
    value label: regulation of histone H3-K36 methylation
  P682:
    value: Q4117777
    source count: 1
    confidence: 0.2
    value label: histone methylation

value: Q14902723
source count: 1
confidence: 0.2
value label: gastrulation with mouth forming second

value: Q14763010
source count: 1
confidence: 0.2
value label: transcription, DNA-templated

value: Q14645705
source count: 1
confidence: 0.2
value label: multicellular organism development

value: Q18252728
source count: 1
confidence: 0.2
value label: Nsd1

value: Q83310
source count: 1
confidence: 0.2
value label: house mouse

source: GOA
stated in qid: Q28018111
retrieved: 2019-02-14

source: Two distinct nuclear receptor interaction domains in NSD1, a novel SET protein that exhibits characteristics of both corepressors and coactivators
stated in qid: Q24336164
retrieved: 2019-02-14

source: NSD1 is essential for early post-implantation development and has a catalytically active SET domain
stated in qid: Q28593118
retrieved: 2019-02-14

source: Identification of potential nuclear reprogramming and differentiation factors by a novel selection method for cloning chromatin-binding proteins
stated in qid: Q28511157
retrieved: 2019-02-14

source: GOA
stated in qid: Q28018111
retrieved: 2018-09-10

source: NSD1 is essential for early post-implantation development and has a catalytically active SET domain
stated in qid: Q28593118
retrieved: 2018-09-10

source: Role for the nuclear receptor-binding SET domain protein 1 (NSD1) methyltransferase in coordinating lysine 36 methylation at histone 3 with RNA polymerase II function
stated in qid: Q24299611
retrieved: 2019-02-14

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-02-14

source: Dynamic histone H3 methylation during gene induction: HYPB/Setd2 mediates all H3K36 trimethylation
stated in qid: Q28593817
retrieved: 2018-09-10

source: Nizp1, a novel multitype zinc finger protein that interacts with the NSD1 histone lysine methyltransferase through a unique C2HR motif
stated in qid: Q28504734
retrieved: 2018-09-10

source: Dynamic histone H3 methylation during gene induction: HYPB/Setd2 mediates all H3K36 trimethylation
stated in qid: Q28593817
retrieved: 2019-02-14

source: Nizp1, a novel multitype zinc finger protein that interacts with the NSD1 histone lysine methyltransferase through a unique C2HR motif
stated in qid: Q28504734
retrieved: 2019-02-14

source: Two distinct nuclear receptor interaction domains in NSD1, a novel SET protein that exhibits characteristics of both corepressors and coactivators
stated in qid: Q24336164
retrieved: 2018-02-27

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2016-08-09

wikidata id: Q21988832
domain: protein
level: standard
html url: https://4ort.xyz/entity/histone-lysine-n-methyltransferase-h3-lysine-36-and-h4-lysine-20-specific
markdown url: https://4ort.xyz/entity/histone-lysine-n-methyltransferase-h3-lysine-36-and-h4-lysine-20-specific.md
facts url summary: https://4ort.xyz/entity/histone-lysine-n-methyltransferase-h3-lysine-36-and-h4-lysine-20-specific/facts.json
facts url standard: https://4ort.xyz/entity/histone-lysine-n-methyltransferase-h3-lysine-36-and-h4-lysine-20-specific/facts.json
facts url full: https://4ort.xyz/entity/histone-lysine-n-methyltransferase-h3-lysine-36-and-h4-lysine-20-specific/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-09T02:11:32.807110Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T15:26:07.980114+00:00Z