# Histone deacetylase 6

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21173381](https://www.wikidata.org/wiki/Q21173381)  
**Source**: https://4ort.xyz/entity/histone-deacetylase-6


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL27759)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL598797)
5. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3622533)
6. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2364628)
7. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL235191)
8. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9UBN7)
9. Q20641742
10. [The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBN7)
11. [HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBN7)
12. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBN7)
13. [Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBN7)
14. [HDAC6 is required for epidermal growth factor-induced beta-catenin nuclear localization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBN7)
15. [The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBN7)
16. [FAM65B controls the proliferation of transformed and primary T cells.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBN7)
17. [The ubiquitin-like modifier FAT10 interacts with HDAC6 and localizes to aggresomes under proteasome inhibition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBN7)
18. [Fam65b is important for formation of the HDAC6-dysferlin protein complex during myogenic cell differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBN7)
19. [Disruption of FAT10-MAD2 binding inhibits tumor progression.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBN7)
20. [Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBN7)
21. [A BBSome subunit links ciliogenesis, microtubule stability, and acetylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBN7)
22. [Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperone](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBN7)
23. [The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBN7)
24. [Identification of novel ATP13A2 interactors and their role in α-synuclein misfolding and toxicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBN7)
25. [PKC alpha regulates Sendai virus-mediated interferon induction through HDAC6 and β-catenin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBN7)
26. [The HTLV-1 Tax protein inhibits formation of stress granules by interacting with histone deacetylase 6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBN7)
27. [CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBN7)
28. [Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBN7)
29. [Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBN7)
30. [A centrosomal Cdc20-APC pathway controls dendrite morphogenesis in postmitotic neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBN7)
31. [A novel GRK2/HDAC6 interaction modulates cell spreading and motility](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBN7)
32. [Histone deacetylase 6 interacts with the microtubule-associated protein tau](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBN7&geneProductId=UniProtKB:Q9UBN7)
33. [HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBN7)
34. [A novel small molecule hydroxamate preferentially inhibits HDAC6 activity and tumour growth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBN7)
35. [Three proteins define a class of human histone deacetylases related to yeast Hda1p](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBN7)
36. [The protein farnesyltransferase regulates HDAC6 activity in a microtubule-dependent manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBN7)
37. [Parkin interacts with Ambra1 to induce mitophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBN7)
38. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBN7&geneProductId=UniProtKB:Q9UBN7)
39. [The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBN7&geneProductId=UniProtKB:Q9UBN7)
40. [The protein farnesyltransferase regulates HDAC6 activity in a microtubule-dependent manner](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBN7&geneProductId=UniProtKB:Q9UBN7)
41. [Differential regulation of estrogen receptor α expression in breast cancer cells by metastasis-associated protein 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBN7)
42. [Histone deacetylase 10 structure and molecular function as a polyamine deacetylase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBN7)
43. [Tau--an inhibitor of deacetylase HDAC6 function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBN7)
44. [Roles of tau protein in health and disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBN7)
45. [Histone deacetylase 6 interacts with the microtubule-associated protein tau](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBN7)
46. [HDAC6 is a microtubule-associated deacetylase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBN7)
47. [ATP13A2 and Alpha-synuclein: a Metal Taste in Autophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBN7)
48. [The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBN7&geneProductId=UniProtKB:Q9UBN7)
49. [Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBN7)
50. [HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBN7)