# Histone deacetylase 6

> mammalian protein found in Mus musculus

**Wikidata**: [Q21979847](https://www.wikidata.org/wiki/Q21979847)  
**Source**: https://4ort.xyz/entity/histone-deacetylase-6-q21979847


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9Z2V5)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V5)
5. [Identification of components of the murine histone deacetylase 6 complex: link between acetylation and ubiquitination signaling pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V5)
6. [Identification of a new family of higher eukaryotic histone deacetylases. Coordinate expression of differentiation-dependent chromatin modifiers](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V5)
7. [CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V5)
8. [HDAC6-p97/VCP controlled polyubiquitin chain turnover](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V5)
9. [The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V5)
10. [Septins promote dendrite and axon development by negatively regulating microtubule stability via HDAC6-mediated deacetylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V5)
11. [A novel GRK2/HDAC6 interaction modulates cell spreading and motility](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V5)
12. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2V5&geneProductId=UniProtKB:Q9Z2V5)
13. [CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2V5&geneProductId=UniProtKB:Q9Z2V5)
14. [HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2V5&geneProductId=UniProtKB:Q9Z2V5)
15. [HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V5)
16. [Tau--an inhibitor of deacetylase HDAC6 function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V5)
17. [AMP Kinase Activation Alters Oxidant-Induced Stress Granule Assembly by Modulating Cell Signaling and Microtubule Organization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V5)
18. [Microtubule deacetylases, SirT2 and HDAC6, in the nervous system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V5)
19. [In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V5)
20. [Microtubule deacetylases, SirT2 and HDAC6, in the nervous system](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Z2V5&geneProductId=UniProtKB:Q9Z2V5)
21. [HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V5)
22. [Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V5)
23. [Regulation of adipogenesis by cytoskeleton remodelling is facilitated by acetyltransferase MEC-17-dependent acetylation of α-tubulin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V5)
24. [Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Z2V5)
25. ensembl Release 106