# Histone deacetylase 4

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21173206](https://www.wikidata.org/wiki/Q21173206)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/HDAC4)  
**Source**: https://4ort.xyz/entity/histone-deacetylase-4


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P56524)
4. Q20641742
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524)
6. [FOXP3 up-regulates p21 expression by site-specific inhibition of histone deacetylase 2/histone deacetylase 4 association to the locus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524)
7. [Three proteins define a class of human histone deacetylases related to yeast Hda1p](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524)
8. [Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524)
9. [Structural and functional analysis of the human HDAC4 catalytic domain reveals a regulatory structural zinc-binding domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524)
10. [HDAC4 represses p21(WAF1/Cip1) expression in human cancer cells through a Sp1-dependent, p53-independent mechanism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524)
11. [Transcriptional activation of hypoxia-inducible factor-1alpha by HDAC4 and HDAC5 involves differential recruitment of p300 and FIH-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524)
12. [The histone deacetylase 9 gene encodes multiple protein isoforms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524)
13. [Differential regulation of estrogen receptor α expression in breast cancer cells by metastasis-associated protein 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524)
14. [The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524)
15. [ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524)
16. [Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524)
17. [Impaired placental trophoblast lineage differentiation in Alkbh1(-/-) mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524)
18. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524)
19. [Differential localization of HDAC4 orchestrates muscle differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524)
20. [Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperone](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524)
21. [Runx3 Inactivation Is a Crucial Early Event in the Development of Lung Adenocarcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524)
22. [Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524)
23. [A human MAP kinase interactome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524)
24. [Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524)
25. [Inhibition of androgen receptor activity by histone deacetylase 4 through receptor SUMOylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524)
26. [CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524)
27. [Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524)
28. [Functional interaction between class II histone deacetylases and ICP0 of herpes simplex virus type 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524)
29. [Identification of the ankyrin repeat proteins ANKRA and RFXANK as novel partners of class IIa histone deacetylases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524)
30. [Epstein-Barr nuclear antigen leader protein coactivates transcription through interaction with histone deacetylase 4.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524)
31. [Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524)
32. [PP2A regulates HDAC4 nuclear import](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524)
33. [JNK-ATF-2 inhibits thrombomodulin (TM) expression by recruiting histone deacetylase4 (HDAC4) and forming a transcriptional repression complex in the TM promoter](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524)
34. [A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524)
35. [The functional interactome landscape of the human histone deacetylase family](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524)
36. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524)
37. [Analysis of BCL6-interacting proteins by tandem mass spectrometry](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524)
38. [Regulation of histone deacetylase 4 by binding of 14-3-3 proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524)
39. [Toward an understanding of the protein interaction network of the human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524)
40. [Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524)
41. [Crystal structure of a conserved N-terminal domain of histone deacetylase 4 reveals functional insights into glutamine-rich domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524)
42. [Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524)
43. [Activation of ROS/NF-kappaB and Ca2+/CaM kinase II are necessary for VCAM-1 induction in IL-1beta-treated human tracheal smooth muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524)
44. [Involvement of Epac1/Rap1/CaMKI/HDAC5 signaling cascade in the regulation of placental cell fusion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524)
45. [Epigenetic changes as a common trigger of muscle weakness in congenital myopathies](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524)
46. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P56524&geneProductId=UniProtKB:P56524)
47. [PC4 coactivates MyoD by relieving the histone deacetylase 4-mediated inhibition of myocyte enhancer factor 2C.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524)
48. [Class II histone deacetylases confer signal responsiveness to the ankyrin-repeat proteins ANKRA2 and RFXANK.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524)
49. [Sumoylation of the zinc finger protein ZXDC enhances the function of its transcriptional activation domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524)
50. [Class II histone deacetylases: versatile regulators](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56524)