# Histone deacetylase 3

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21154358](https://www.wikidata.org/wiki/Q21154358)  
**Source**: https://4ort.xyz/entity/histone-deacetylase-3-q21154358


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL27759)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL598797)
5. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3622533)
6. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL235191)
7. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O15379)
8. Q20641742
9. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379)
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O15379&geneProductId=UniProtKB:O15379)
11. [Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1](http://www.ebi.ac.uk/QuickGO/annotations?protein=O15379&geneProductId=UniProtKB:O15379)
12. [INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases](http://www.ebi.ac.uk/QuickGO/annotations?protein=O15379&geneProductId=UniProtKB:O15379)
13. [Identification of an INSM1-binding site in the insulin promoter: negative regulation of the insulin gene transcription](http://www.ebi.ac.uk/QuickGO/annotations?protein=O15379&geneProductId=UniProtKB:O15379)
14. [Class II histone deacetylases: versatile regulators](http://www.ebi.ac.uk/QuickGO/annotations?protein=O15379&geneProductId=UniProtKB:O15379)
15. [Histone deacetylases specifically down-regulate p53-dependent gene activation](http://www.ebi.ac.uk/QuickGO/annotations?protein=O15379&geneProductId=UniProtKB:O15379)
16. [A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=O15379&geneProductId=UniProtKB:O15379)
17. [Histone deacetylase 3 localizes to the mitotic spindle and is required for kinetochore-microtubule attachment](http://www.ebi.ac.uk/QuickGO/annotations?protein=O15379&geneProductId=UniProtKB:O15379)
18. [Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3'-end processing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379)
19. [Class II histone deacetylases: versatile regulators](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379)
20. [INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379)
21. [Involvement of Epac1/Rap1/CaMKI/HDAC5 signaling cascade in the regulation of placental cell fusion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379)
22. [The histone deacetylase 9 gene encodes multiple protein isoforms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379)
23. [Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379)
24. [Identification of an INSM1-binding site in the insulin promoter: negative regulation of the insulin gene transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379)
25. [LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379)
26. [The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379)
27. [Ataxin 1, a SCA1 neurodegenerative disorder protein, is functionally linked to the silencing mediator of retinoid and thyroid hormone receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379)
28. [Receptor-interacting protein 140 directly recruits histone deacetylases for gene silencing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379)
29. [NKAP is a transcriptional repressor of notch signaling and is required for T cell development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379)
30. [A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379)
31. [Transcription-dependent nucleolar cap localization and possible nuclear function of DExH RNA helicase RHAU.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379)
32. [Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379)
33. [A BEN-domain-containing protein associates with heterochromatin and represses transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379)
34. [Histone deacetylase 10 regulates DNA mismatch repair and may involve the deacetylation of MutS homolog 2.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379)
35. [HDAC3 Is Negatively Regulated by the Nuclear Protein DBC1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379)
36. [Unspliced X-box-binding Protein 1 (XBP1) Protects Endothelial Cells from Oxidative Stress through Interaction with Histone Deacetylase 3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379)
37. [FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379)
38. [BCoR, a novel corepressor involved in BCL-6 repression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379)
39. [Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379)
40. [Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379)
41. [Activation of p53 Transcriptional Activity by SMRT: a Histone Deacetylase 3-Independent Function of a Transcriptional Corepressor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379)
42. [Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379)
43. [Cyclin D1b variant influences prostate cancer growth through aberrant androgen receptor regulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379)
44. [The methyl-CpG binding protein MBD1 is required for PML-RARalpha function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379)
45. [A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379)
46. [A novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379)
47. [Global landscape of HIV-human protein complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379)
48. [Involvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379)
49. [Insulin and mTOR Pathway Regulate HDAC3-Mediated Deacetylation and Activation of PGK1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379)
50. [Functional interaction between class II histone deacetylases and ICP0 of herpes simplex virus type 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15379)