# histone deacetylase 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q5773155](https://www.wikidata.org/wiki/Q5773155)  
**Source**: https://4ort.xyz/entity/histone-deacetylase-2-q5773155


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [BioGRID](https://thebiogrid.org/news/227)
4. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q92769)
5. Q20641742
6. [Heterogeneous nuclear ribonucleoprotein C1/C2, MeCP1, and SWI/SNF form a chromatin remodeling complex at the beta-globin locus control region](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92769&geneProductId=UniProtKB:Q92769)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769)
8. [Differential distribution of unmodified and phosphorylated histone deacetylase 2 in chromatin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769)
9. [FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769)
10. [Histone deacetylase interacts directly with DNA topoisomerase II](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769)
11. [HDAC2 deacetylates class II transactivator and suppresses its activity in macrophages and smooth muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769)
12. [LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769)
13. [Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769)
14. [Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769)
15. [The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769)
16. [Histone deacetylase 10 regulates DNA mismatch repair and may involve the deacetylation of MutS homolog 2.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769)
17. [The subcellular distribution and function of MTA1 in cancer differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769)
18. [Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769)
19. [The transcriptional repressor Sp3 is associated with CK2-phosphorylated histone deacetylase 2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769)
20. [SUMOylation and SUMO-interacting Motif (SIM) of Metastasis Tumor Antigen 1 (MTA1) Synergistically Regulate Its Transcriptional Repressor Function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769)
21. [Chfr is linked to tumour metastasis through the downregulation of HDAC1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769)
22. [Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769)
23. [Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769)
24. [A BEN-domain-containing protein associates with heterochromatin and represses transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769)
25. [E3 ubiquitin ligase COP1 regulates the stability and functions of MTA1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769)
26. [Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769)
27. [FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769)
28. [Dual role of NRSF/REST in activation and repression of the glucocorticoid response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769)
29. [Acetylation of Snail Modulates the Cytokinome of Cancer Cells to Enhance the Recruitment of Macrophages](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769)
30. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769)
31. [Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769)
32. [Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769)
33. [Nucleophosmin acts as a novel AP2alpha-binding transcriptional corepressor during cell differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769)
34. [Orphan nuclear receptor Nur77 induces zinc finger protein GIOT-1 gene expression, and GIOT-1 acts as a novel corepressor of orphan nuclear receptor SF-1 via recruitment of HDAC2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769)
35. [Acetylation-dependent oncogenic activity of metastasis-associated protein 1 co-regulator](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769)
36. [Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperone](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769)
37. [Dysfunction of the Reciprocal Feedback Loop between GATA3- and ZEB2-Nucleated Repression Programs Contributes to Breast Cancer Metastasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769)
38. [A Comprehensive Resource of Interacting Protein Regions for Refining Human Transcription Factor Networks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769)
39. [Recruitment of chromatin-modifying enzymes by CTIP2 promotes HIV-1 transcriptional silencing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769)
40. [The steroid receptor RNA activator protein is recruited to promoter regions and acts as a transcriptional repressor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769)
41. [The ErbB3 binding protein Ebp1 interacts with Sin3A to repress E2F1 and AR-mediated transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769)
42. [Isolation and Characterization of a Novel Class II Histone Deacetylase, HDAC10](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769)
43. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769)
44. [Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769)
45. [NuRD-ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769)
46. [Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769)
47. [The functional interactome landscape of the human histone deacetylase family](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769)
48. [Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769)
49. [Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769)
50. [Regulatory factor for X-box family proteins differentially interact with histone deacetylases to repress collagen alpha2(I) gene (COL1A2) expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769)