# histone deacetylase 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q5629167](https://www.wikidata.org/wiki/Q5629167)  
**Source**: https://4ort.xyz/entity/histone-deacetylase-1


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL27759)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL598797)
5. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3622533)
6. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL235191)
7. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q13547)
8. Q20641742
9. [Heterogeneous nuclear ribonucleoprotein C1/C2, MeCP1, and SWI/SNF form a chromatin remodeling complex at the beta-globin locus control region](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13547&geneProductId=UniProtKB:Q13547)
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547)
11. [Modulation of the expression and transactivation of androgen receptor by the basic helix-loop-helix transcription factor Pod-1 through recruitment of histone deacetylase 1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13547&geneProductId=UniProtKB:Q13547)
12. [Class II histone deacetylases: versatile regulators](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13547&geneProductId=UniProtKB:Q13547)
13. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13547&geneProductId=UniProtKB:Q13547)
14. [Chfr is linked to tumour metastasis through the downregulation of HDAC1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13547&geneProductId=UniProtKB:Q13547)
15. [The orphan nuclear receptor Rev-erbbeta recruits Tip60 and HDAC1 to regulate apolipoprotein CIII promoter](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13547&geneProductId=UniProtKB:Q13547)
16. [HDAC1 acetylation is linked to progressive modulation of steroid receptor-induced gene transcription](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13547&geneProductId=UniProtKB:Q13547)
17. [Functional architecture of atrophins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547)
18. [Isolation and mapping of a human gene (RPD3L1) that is homologous to RPD3, a transcription factor in Saccharomyces cerevisiae](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13547&geneProductId=UniProtKB:Q13547)
19. [Chfr is linked to tumour metastasis through the downregulation of HDAC1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547)
20. [Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3'-end processing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547)
21. [Deacetylation of p53 induces autophagy by suppressing Bmf expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547)
22. [Differential HDAC1 and 2 Recruitment by Members of the MIER Family](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547)
23. [The histone deacetylase 9 gene encodes multiple protein isoforms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547)
24. [LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547)
25. [FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547)
26. [The transcriptional repressor Sp3 is associated with CK2-phosphorylated histone deacetylase 2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547)
27. [Involvement of a novel zinc finger protein, MIZF, in transcriptional repression by interacting with a methyl-CpG-binding protein, MBD2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547)
28. [SKI and MEL1 cooperate to inhibit transforming growth factor-beta signal in gastric cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547)
29. [FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547)
30. [The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547)
31. [HDAC1, a histone deacetylase, forms a complex with Hus1 and Rad9, two G2/M checkpoint Rad proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547)
32. [Transcription-dependent nucleolar cap localization and possible nuclear function of DExH RNA helicase RHAU.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547)
33. [Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547)
34. [Human CD1D Gene Expression Is Regulated by LEF-1 through Distal Promoter Regulatory Elements](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547)
35. [A calcium-dependent switch in a CREST-BRG1 complex regulates activity-dependent gene expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547)
36. [Epigenetic regulation of protein-coding and microRNA genes by the Gfi1-interacting tumor suppressor PRDM5](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547)
37. [Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547)
38. [Acetylation of Sirt2 by p300 attenuates its deacetylase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547)
39. [PHF6 Interacts with the Nucleosome Remodeling and Deacetylation (NuRD) Complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547)
40. [Nuclear tumor necrosis factor receptor-associated factor 6 in lymphoid cells negatively regulates c-Myb-mediated transactivation through small ubiquitin-related modifier-1 modification](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547)
41. [HDAC3 Is Negatively Regulated by the Nuclear Protein DBC1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547)
42. [Receptor-interacting protein 140 directly recruits histone deacetylases for gene silencing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547)
43. [Respiratory syncytial virus-inducible BCL-3 expression antagonizes the STAT/IRF and NF-kappaB signaling pathways by inducing histone deacetylase 1 recruitment to the interleukin-8 promoter](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547)
44. [Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547)
45. [Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547)
46. [Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547)
47. [Transcriptional repression of human immunodeficiency virus type 1 by AP-4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547)
48. [Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547)
49. [Site-specific acetylation of the fetal globin activator NF-E4 prevents its ubiquitination and regulates its interaction with the histone deacetylase, HDAC1.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547)
50. [NAPP2, a peroxisomal membrane protein, is also a transcriptional corepressor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13547)