# Histidine rich glycoprotein

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21155914](https://www.wikidata.org/wiki/Q21155914)  
**Source**: https://4ort.xyz/entity/histidine-rich-glycoprotein


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P04196)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04196&geneProductId=UniProtKB:P04196)
5. [The anti-angiogenic His/Pro-rich fragment of histidine-rich glycoprotein binds to endothelial cell heparan sulfate in a Zn2+-dependent manner](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04196&geneProductId=UniProtKB:P04196)
6. [Histidine-rich glycoprotein binds factor XIIa with high affinity and inhibits contact-initiated coagulation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04196&geneProductId=UniProtKB:P04196)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196)
8. [Histidine-rich glycoprotein binds to cell-surface heparan sulfate via its N-terminal domain following Zn2+ chelation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04196&geneProductId=UniProtKB:P04196)
9. [Differential binding of histidine-rich glycoprotein (HRG) to human IgG subclasses and IgG molecules containing kappa and lambda light chains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196)
10. [Human serum histidine-rich glycoprotein. I. Interactions with heme, metal ions and organic ligands](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196)
11. [Histidine-rich glycoprotein binds heparanase and regulates its enzymatic activity and cell surface interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196)
12. [Regulation of histidine-rich glycoprotein (HRG) function via plasmin-mediated proteolytic cleavage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196)
13. [Histidine-rich glycoprotein inhibits the antiangiogenic effect of thrombospondin-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196)
14. [Histidine-rich glycoprotein binds factor XIIa with high affinity and inhibits contact-initiated coagulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196)
15. [High affinity interaction between histidine-rich glycoprotein and the cell surface type ATP synthase on T-cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196)
16. [Plasminogen is tethered with high affinity to the cell surface by the plasma protein, histidine-rich glycoprotein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196)
17. [Functional and structural properties of a novel protein and virulence factor (Protein sHIP) in Streptococcus pyogenes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196)
18. [Toward an understanding of the protein interaction network of the human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196)
19. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196)
20. [Histidine-rich glycoprotein binds to cell-surface heparan sulfate via its N-terminal domain following Zn2+ chelation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196)
21. [The anti-angiogenic His/Pro-rich fragment of histidine-rich glycoprotein binds to endothelial cell heparan sulfate in a Zn2+-dependent manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196)
22. [Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04196&geneProductId=UniProtKB:P04196)
23. [The human plasma proteome: a nonredundant list developed by combination of four separate sources](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04196&geneProductId=UniProtKB:P04196)
24. [Histidine-rich glycoprotein protects from systemic Candida infection](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04196&geneProductId=UniProtKB:P04196)
25. [Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04196&geneProductId=UniProtKB:P04196)
26. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04196&geneProductId=UniProtKB:P04196)
27. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04196&geneProductId=UniProtKB:P04196)
28. [Proteomic analysis of podocyte exosome-enriched fraction from normal human urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04196&geneProductId=UniProtKB:P04196)
29. [The human plasma proteome: a nonredundant list developed by combination of four separate sources](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196)
30. [Histidine-rich glycoprotein protects from systemic Candida infection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196)
31. [Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196)
32. [Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196)
33. [Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196)
34. [Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196)
35. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196)
36. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196)
37. [Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196)
38. [A fragment of histidine-rich glycoprotein is a potent inhibitor of tumor vascularization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196)
39. [Minimal active domain and mechanism of action of the angiogenesis inhibitor histidine-rich glycoprotein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196)
40. [HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196)
41. [Activated platelets provide a functional microenvironment for the antiangiogenic fragment of histidine-rich glycoprotein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196)
42. [Histidine-rich glycoprotein modulates the anticoagulant activity of heparin in human plasma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04196)
43. Ensembl Release 99