# High-Order Epistasis in Catalytic Power of Dihydrofolate Reductase Gives Rise to a Rugged Fitness Landscape in the Presence of Trimethoprim Selection

> Research article (Molecular Biology and Evolution, 2019) · cited 84× · AI/ML

**Wikidata**: [openalex:W2950343954](https://www.wikidata.org/wiki/openalex:W2950343954)  
**Source**: https://4ort.xyz/entity/high-order-epistasis-in-catalytic-power-of-dihydrofolate-reductase-gives-rise-to-a-rugged-fitness-landscape-in-the-prese