# High mobility group box 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21130552](https://www.wikidata.org/wiki/Q21130552)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/HMGB1)  
**Source**: https://4ort.xyz/entity/high-mobility-group-box-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P09429)
3. Q20641742
4. [HMGB1 and HMGB2 proteins up-regulate cellular expression of human topoisomerase IIalpha](http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429)
6. [HMGB1 is a cofactor in mammalian base excision repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429)
7. [HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429)
8. [High mobility group protein-1 inhibits phagocytosis of apoptotic neutrophils through binding to phosphatidylserine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429)
9. [Identification of lipopolysaccharide‐binding peptide regions within HMGB1 and their effects on subclinical endotoxemia in a mouse model](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429)
10. [Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429)
11. [HMGB1 and HMGB2 cell-specifically down-regulate the p53- and p73-dependent sequence-specific transactivation from the human Bax gene promoter](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429)
12. [High mobility group protein-1 (HMG-1) is a unique activator of p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429)
13. [The high mobility group protein HMG1 can reversibly inhibit class II gene transcription by interaction with the TATA-binding protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429)
14. [Chaperone-like activity of high-mobility group box 1 protein and its role in reducing the formation of polyglutamine aggregates](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429)
15. [Endogenous HMGB1 regulates autophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429)
16. [Evidence for involvement of HMGB1 protein in human DNA mismatch repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429)
17. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429)
18. [HMGB1-Facilitated p53 DNA Binding Occurs via HMG-Box/p53 Transactivation Domain Interaction, Regulated by the Acidic Tail](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429)
19. [An immunogenic peptide in the A-box of HMGB1 protein reverses apoptosis-induced tolerance through RAGE receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429)
20. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429)
21. [Insights into RNA biology from an atlas of mammalian mRNA-binding proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429)
22. [The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts](http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429)
23. [HMGB1 and HMGB2 proteins up-regulate cellular expression of human topoisomerase IIalpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429)
24. [The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429)
25. [Insights into RNA biology from an atlas of mammalian mRNA-binding proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429)
26. [HMGB1 inhibits macrophage activity in efferocytosis through binding to the alphavbeta3-integrin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429)
27. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429)
28. [Chromatin-specific remodeling by HMGB1 and linker histone H1 silences proinflammatory genes during endotoxin tolerance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429)
29. [The nonspecific DNA-binding and -bending proteins HMG1 and HMG2 promote the assembly of complex nucleoprotein structures](http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429)
30. [Linking innate and adaptive immunity: human Vgamma9Vdelta2 T cells enhance CD40 expression and HMGB-1 secretion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429)
31. [Association of chromatin proteins high mobility group box (HMGB) 1 and HMGB2 with mitotic chromosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429)
32. [Linking innate and adaptive immunity: human Vgamma9Vdelta2 T cells enhance CD40 expression and HMGB-1 secretion](http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429)
33. [The nonspecific DNA-binding and -bending proteins HMG1 and HMG2 promote the assembly of complex nucleoprotein structures](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429)
34. [HMGB1 conveys immunosuppressive characteristics on regulatory and conventional T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429)
35. [HMGB1 and HMGB2 cell-specifically down-regulate the p53- and p73-dependent sequence-specific transactivation from the human Bax gene promoter](http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429)
36. [Structural basis for the proinflammatory cytokine activity of high mobility group box 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429)
37. [Effect of high mobility group box-1 protein on apoptosis of peritoneal macrophages](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429)
38. [Release of high mobility group box 1 by dendritic cells controls T cell activation via the receptor for advanced glycation end products](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429)
39. [High mobility group Box 1 inhibits human pulmonary artery endothelial cell migration via a Toll-like receptor 4- and interferon response factor 3-dependent mechanism(s)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429)
40. [HMGB1–DNA complex-induced autophagy limits AIM2 inflammasome activation through RAGE](http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429)
41. [Emodin-6-O-β-d-glucoside inhibits HMGB1-induced inflammatory responses in vitro and in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429)
42. [Chromatin-specific remodeling by HMGB1 and linker histone H1 silences proinflammatory genes during endotoxin tolerance](http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429)
43. [V(D)J recombination: modulation of RAG1 and RAG2 cleavage activity on 12/23 substrates by whole cell extract and DNA-bending proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429)
44. [Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein](http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429)
45. [Endogenous HMGB1 regulates autophagy](http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429)
46. [HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4](http://www.ebi.ac.uk/QuickGO/annotations?protein=P09429&geneProductId=UniProtKB:P09429)
47. [HMGB1–DNA complex-induced autophagy limits AIM2 inflammasome activation through RAGE](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429)
48. [Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429)
49. [miR-193a-3p interaction with HMGB1 downregulates human endothelial cell proliferation and migration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09429)
50. Ensembl Release 99