# High mobility group box 1

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28560462](https://www.wikidata.org/wiki/Q28560462)  
**Source**: https://4ort.xyz/entity/high-mobility-group-box-1-q28560462


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P63159)
3. Q20641742
4. [The DNA binding site of HMG1 protein is composed of two similar segments (HMG boxes), both of which have counterparts in other eukaryotic regulatory proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159)
5. [A role of basic residues and the putative intercalating phenylalanine of the HMG-1 box B in DNA supercoiling and binding to four-way DNA junctions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159)
7. [DNA binding by single HMG box model proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159)
8. [Recombinant HMGB1 with cytokine-stimulating activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159)
9. [Extracellular HMGB1, a signal of tissue damage, induces mesoangioblast migration and proliferation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159)
10. [Borna Disease Virus Phosphoprotein Represses p53-Mediated Transcriptional Activity by Interference with HMGB1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159)
11. [alpha-Synuclein filaments bind the transcriptional regulator HMGB-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159)
12. [Interactions of recombinant HMGB proteins with branched RNA substrates](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159)
13. [HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159)
14. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159)
15. [30-kDa heparin-binding protein of brain (amphoterin) involved in neurite outgrowth. Amino acid sequence and localization in the filopodia of the advancing plasma membrane](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159)
16. [Identity of nuclear high-mobility-group protein, HMG-1, and sulfoglucuronyl carbohydrate-binding protein, SBP-1, in brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159)
17. [HMGB binding to DNA: single and double box motifs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159)
18. [The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin. Mediation of neurite outgrowth and co-expression of rage and amphoterin in the developing nervous system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159)
19. [High mobility group B1 protein interacts with its receptor RAGE in tumor cells but not in normal tissues](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159)
20. [RAGE is the major receptor for the proinflammatory activity of HMGB1 in rodent macrophages](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159)
21. [Recombinant thrombomodulin prevents heatstroke by inhibition of high-mobility group box 1 protein in sera of rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159)
22. [Tanshinone II A down-regulates HMGB1, RAGE, TLR4, NF-kappaB expression, ameliorates BBB permeability and endothelial cell function, and protects rat brains against focal ischemia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159)
23. [Proteomic characterisation of neuronal sphingolipid-cholesterol microdomains: role in plasminogen activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159)
24. [Intraocular expression and release of high-mobility group box 1 protein in retinal detachment](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159)
25. [Diurnal rhythm of the chromatin protein Hmgb1 in rat photoreceptors is under circadian regulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159)
26. [HMGB1 protein inhibits DNA replication in vitro: a role of the acetylation and the acidic tail](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159)
27. [High-mobility group box 1 protein activates hepatic stellate cells in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159)
28. [Effects of hyperglycemia and insulin therapy on high mobility group box 1 in endotoxin-induced acute lung injury in a rat model](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159)
29. [Knocking down HMGB1 using dendrimer-delivered siRNA unveils its key role in NMDA-induced autophagy in rat cortical neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159)
30. [Neuroprotection by biodegradable PAMAM ester (e-PAM-R)-mediated HMGB1 siRNA delivery in primary cortical cultures and in the postischemic brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159)
31. [Borna disease virus phosphoprotein binds a neurite outgrowth factor, amphoterin/HMG-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159)
32. [The high mobility group (HMG) boxes of the nuclear protein HMG1 induce chemotaxis and cytoskeleton reorganization in rat smooth muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159)
33. [The effect of experimental diabetes on high mobility group box 1 protein expression in endotoxin-induced acute lung injury](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159)
34. [High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159)
35. [Oxidation of HMGB1 causes attenuation of its pro-inflammatory activity and occurs during liver ischemia and reperfusion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159)
36. [Insulin attenuates the systemic inflammatory response in endotoxemic rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159)
37. [Effects of HMGB1 on PMN apoptosis during LPS-induced acute lung injury](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159)
38. [Alveolar macrophage suppression in sepsis is associated with high mobility group box 1 transmigration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159)
39. [The amphoterin (HMGB1)/receptor for advanced glycation end products (RAGE) pair modulates myoblast proliferation, apoptosis, adhesiveness, migration, and invasiveness. Functional inactivation of RAGE in L6 myoblasts results in tumor formation in viv](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159)
40. [Amphoterin stimulates myogenesis and counteracts the antimyogenic factors basic fibroblast growth factor and S100B via RAGE binding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159)
41. [Modulated inflammation by injection of high-mobility group box 1 recovers post-infarction chronically failing heart](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159)
42. [The high mobility group box chromosomal protein 1 is expressed in the human and rat testis where it may function as an antibacterial factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159)
43. [HMG1 protein stimulates DNA end joining by promoting association of DNA molecules via their ends](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159)
44. [Interleukin-1 stimulates beta-cell necrosis and release of the immunological adjuvant HMGB1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63159)
45. ensembl Release 104