# High mobility group AT-hook 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q5630986](https://www.wikidata.org/wiki/Q5630986)  
**Source**: https://4ort.xyz/entity/high-mobility-group-at-hook-2


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P52926)
3. Q20641742
4. [Expression and cDNA cloning of human HMGI-C phosphoprotein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52926)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52926)
6. [Suppression of nonhomologous end joining repair by overexpression of HMGA2](http://www.ebi.ac.uk/QuickGO/annotations?protein=P52926&geneProductId=UniProtKB:P52926)
7. [HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52926)
8. [HMGA2 exhibits dRP/AP site cleavage activity and protects cancer cells from DNA-damage-induced cytotoxicity during chemotherapy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52926)
9. [Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52926)
10. [High-level expression of DNA architectural factor HMGA2 and its association with nucleosomes in human embryonic stem cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52926)
11. [HMGA2 regulates transcription of the Imp2 gene via an intronic regulatory element in cooperation with nuclear factor-kappaB](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52926)
12. [High mobility group A2 protein and its derivatives bind a specific region of the promoter of DNA repair gene ERCC1 and modulate its activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52926)
13. [Chromatin Immunoprecipitation to Analyze DNA Binding Sites of HMGA2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52926)
14. [DNA bending by the mammalian high-mobility group protein AT hook 2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52926)
15. [HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition](http://www.ebi.ac.uk/QuickGO/annotations?protein=P52926&geneProductId=UniProtKB:P52926)
16. [Transcriptional activation of the cyclin A gene by the architectural transcription factor HMGA2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52926)
17. [High mobility group A2 protein and its derivatives bind a specific region of the promoter of DNA repair gene ERCC1 and modulate its activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P52926&geneProductId=UniProtKB:P52926)
18. [The second AT-hook of the architectural transcription factor HMGA2 is determinant for nuclear localization and function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52926)
19. [The AT-hook of the chromatin architectural transcription factor high mobility group A1a is arginine-methylated by protein arginine methyltransferase 6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52926)
20. [HMGA2 exhibits dRP/AP site cleavage activity and protects cancer cells from DNA-damage-induced cytotoxicity during chemotherapy](http://www.ebi.ac.uk/QuickGO/annotations?protein=P52926&geneProductId=UniProtKB:P52926)
21. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52926)
22. [A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52926)
23. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P52926&geneProductId=UniProtKB:P52926)
24. [A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P52926&geneProductId=UniProtKB:P52926)
25. [The second AT-hook of the architectural transcription factor HMGA2 is determinant for nuclear localization and function](http://www.ebi.ac.uk/QuickGO/annotations?protein=P52926&geneProductId=UniProtKB:P52926)
26. [High-level expression of DNA architectural factor HMGA2 and its association with nucleosomes in human embryonic stem cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P52926&geneProductId=UniProtKB:P52926)
27. [Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=P52926&geneProductId=UniProtKB:P52926)
28. [Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52926)
29. [Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains](http://www.ebi.ac.uk/QuickGO/annotations?protein=P52926&geneProductId=UniProtKB:P52926)
30. [DNA architectural factor and proto-oncogene HMGA2 regulates key developmental genes in pluripotent human embryonic stem cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52926)
31. [High-mobility group protein HMGA2-derived fragments stimulate the proliferation of chondrocytes and adipose tissue-derived stem cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52926)
32. [High mobility group A2 potentiates genotoxic stress in part through the modulation of basal and DNA damage-dependent phosphatidylinositol 3-kinase-related protein kinase activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52926)
33. [Transcriptional activation of the cyclin A gene by the architectural transcription factor HMGA2](http://www.ebi.ac.uk/QuickGO/annotations?protein=P52926&geneProductId=UniProtKB:P52926)
34. [Repression of HMGA2 gene expression by human cytomegalovirus involves the IE2 86-kilodalton protein and is necessary for efficient viral replication and inhibition of cyclin A transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52926)
35. [The high mobility group protein HMGA2: a co-regulator of chromatin structure and pluripotency in stem cells?](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52926)
36. [Transactivation functions of the tumor-specific HMGA2/LPP fusion protein are augmented by wild-type HMGA2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52926)
37. [Differential regulation of the insulin-like growth factor II mRNA-binding protein genes by architectural transcription factor HMGA2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52926)
38. [Suppression of nonhomologous end joining repair by overexpression of HMGA2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52926)
39. Ensembl Release 99
40. [Identifiers.org](https://registry.identifiers.org/registry/uniprot)
41. UMLS 2023