# Hexosaminidase A

> mammalian protein found in Mus musculus

**Wikidata**: [Q21984075](https://www.wikidata.org/wiki/Q21984075)  
**Source**: https://4ort.xyz/entity/hexosaminidase-a


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P29416)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29416)
5. [Targeted disruption of the Hexa gene results in mice with biochemical and pathologic features of Tay-Sachs disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29416)
6. [Adenoviral gene therapy of the Tay-Sachs disease in hexosaminidase A-deficient knock-out mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29416)
7. [Disruption of murine Hexa gene leads to enzymatic deficiency and to neuronal lysosomal storage, similar to that observed in Tay-Sachs disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29416)
8. [Dramatically different phenotypes in mouse models of human Tay-Sachs and Sandhoff diseases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29416)
9. [Mice lacking both subunits of lysosomal beta-hexosaminidase display gangliosidosis and mucopolysaccharidosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29416)
10. [Specificity of mouse GM2 activator protein and beta-N-acetylhexosaminidases A and B. Similarities and differences with their human counterparts in the catabolism of GM2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29416)
11. [Dynamics of major histocompatibility complex class II compartments during B cell receptor-mediated cell activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29416)
12. [Chromosomal assignments of 23 biochemical loci of the rat by using rat x mouse somatic cell hybrids](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29416)
13. [Characterization of the testis and epididymis in mouse models of human Tay Sachs and Sandhoff diseases and partial determination of accumulated gangliosides](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29416)
14. [Mice deficient in all forms of lysosomal beta-hexosaminidase show mucopolysaccharidosis-like pathology](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29416)
15. [TGF-β/Smad2/3 signaling directly regulates several miRNAs in mouse ES cells and early embryos](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29416)
16. [Late onset Tay-Sachs disease in mice with targeted disruption of the Hexa gene: behavioral changes and pathology of the central nervous system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29416)
17. [A genetic model of substrate deprivation therapy for a glycosphingolipid storage disorder](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29416)
18. [Mouse model of G M2 activator deficiency manifests cerebellar pathology and motor impairment](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29416)
19. [Apoptotic Cell Death in Mouse Models of GM2 Gangliosidosis and Observations on Human Tay-Sachs and Sandhoff Diseases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29416)
20. [II. Characterization and development of the regional- and cellular-specific abnormalities in the epididymis of mice with beta-hexosaminidase A deficiency](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29416)
21. [Prevention of lysosomal storage in Tay-Sachs mice treated with N-butyldeoxynojirimycin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29416)
22. ensembl Release 106