# hereditary spastic paraplegia 7

> hereditary spastic paraplegia that is characterized by slowly progressive onset, usually between 18-60 years of age, and generally more severe spasticity and has material basis in mutation in the SPG7 gene on chromosome 16q24

**Wikidata**: [Q3363626](https://www.wikidata.org/wiki/Q3363626)  
**Source**: https://4ort.xyz/entity/hereditary-spastic-paraplegia-7


## References

1. Monarch Disease Ontology release 2018-06-29
2. Disease Ontology
3. UniProt
4. Spastic paraplegia and OXPHOS impairment caused by mutations in paraplegin, a nuclear-encoded mitochondrial metalloprotease
5. [Open Targets Platform](https://platform.opentargets.org/evidence/ENSG00000197912/MONDO_0011803)
6. [Open Targets Platform](https://platform.opentargets.org/evidence/ENSG00000197912/Orphanet_99013)
7. [Identifiers.org](https://registry.identifiers.org/registry/doid)