# Hepatocyte nuclear factor 4 alpha

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21114166](https://www.wikidata.org/wiki/Q21114166)  
**Source**: https://4ort.xyz/entity/hepatocyte-nuclear-factor-4-alpha


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235)
5. [Intestinal apolipoprotein AI gene transcription is regulated by multiple distinct DNA elements and is synergistically activated by the orphan nuclear receptor, hepatocyte nuclear factor 4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235)
6. [Mitogen-activated protein kinase regulates transcription of the ApoCIII gene. Involvement of the orphan nuclear receptor HNF4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235)
7. [Functional characterization of transcription factor binding sites for HNF1-alpha, HNF3-beta (FOXA2), HNF4-alpha, Sp1 and Sp3 in the human prothrombin gene enhancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235)
8. [A Prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4alpha that regulates the cholesterol 7alpha-hydroxylase gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235)
9. [Regulation of alpha1-antitrypsin gene expression in human intestinal epithelial cell line caco-2 by HNF-1alpha and HNF-4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235)
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P41235&geneProductId=UniProtKB:P41235)
11. [Nuclear receptor HNF4A transrepresses CLOCK:BMAL1 and modulates tissue-specific circadian networks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235)
12. [PKA-dependent regulation of the histone lysine demethylase complex PHF2-ARID5B](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235)
13. [Functional dissection of the alpha-synuclein promoter: transcriptional regulation by ZSCAN21 and ZNF219](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235)
14. [Multiple binding modes between HNF4alpha and the LXXLL motifs of PGC-1alpha lead to full activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235)
15. [Sterol regulatory element-binding protein-2 interacts with hepatocyte nuclear factor-4 to enhance sterol isomerase gene expression in hepatocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235)
16. [Cited2, a coactivator of HNF4alpha, is essential for liver development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235)
17. [Dexamethasone-mediated up-regulation of human CYP2A6 involves the glucocorticoid receptor and increased binding of hepatic nuclear factor 4 alpha to the proximal promoter](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235)
18. [FOXO6 promotes gastric cancer cell tumorigenicity via upregulation of C‐myc](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235)
19. [Transcription of the human microsomal epoxide hydrolase gene (EPHX1) is regulated by an HNF-4α/CAR/RXR/PSF complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235)
20. [Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235)
21. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?protein=P41235&geneProductId=UniProtKB:P41235)
22. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235)
23. [Role of a BCL9-related beta-catenin-binding protein, B9L, in tumorigenesis induced by aberrant activation of Wnt signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235)
24. [A Crucial Role of Hepatocyte Nuclear Factor-4 Expression in the Differentiation of Human Ductular Hepatocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235)
25. [Role of human hepatocyte nuclear factor 4alpha in the expression of drug-metabolizing enzymes and transporters in human hepatocytes assessed by use of small interfering RNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235)
26. [HNF4 alpha orchestrates a set of 14 genes to down-regulate cell proliferation in kidney cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235)
27. [Expression of the hepatic specific V1 messenger ribonucleic acid of the human growth hormone receptor gene is regulated by hepatic nuclear factor (HNF)-4alpha2 and HNF-4alpha8](http://www.ebi.ac.uk/QuickGO/annotations?protein=P41235&geneProductId=UniProtKB:P41235)
28. [Role of human hepatocyte nuclear factor 4alpha in the expression of drug-metabolizing enzymes and transporters in human hepatocytes assessed by use of small interfering RNA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P41235&geneProductId=UniProtKB:P41235)
29. [HNF4A Regulates the Formation of Hepatic Progenitor Cells from Human iPSC-Derived Endoderm by Facilitating Efficient Recruitment of RNA Pol II](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235)
30. Ensembl Release 99
31. Identifiers.org