# Hepatocyte nuclear factor 4, alpha

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28563180](https://www.wikidata.org/wiki/Q28563180)  
**Source**: https://4ort.xyz/entity/hepatocyte-nuclear-factor-4-alpha-q28563180


## References

1. UniProt
2. Q20641742
3. [Thioesterase activity and acyl-CoA/fatty acid cross-talk of hepatocyte nuclear factor-4{alpha}](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22449)
4. [Functional characterization of hepatocyte nuclear factor-4 alpha dimerization interface mutants.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22449)
5. [Hepatocyte nuclear factor-4α interacts with other hepatocyte nuclear factors in regulating transthyretin gene expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22449)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22449)
7. [Transcriptional regulation of the glucose-6-phosphatase gene by cAMP/vasoactive intestinal peptide in the intestine. Role of HNF4alpha, CREM, HNF1alpha, and C/EBPalpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22449)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P22449&geneProductId=UniProtKB:P22449)
9. [Physical and Functional Interaction of Acyl-CoA-binding Protein with Hepatocyte Nuclear Factor-4α](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22449)
10. [Liver-type fatty acid binding protein interacts with hepatocyte nuclear factor 4α](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22449)
11. [Hepatocyte nuclear factor-4alpha contributes to carbohydrate-induced transcriptional activation of hepatic fatty acid synthase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22449)
12. [Ligand specificity and conformational dependence of the hepatic nuclear factor-4alpha (HNF-4alpha ).](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22449)
13. [Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22449)
14. [Proteomics profiling of nuclear proteins for kidney fibroblasts suggests hypoxia, meiosis, and cancer may meet in the nucleus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22449)
15. [DAX-1 acts as a novel corepressor of orphan nuclear receptor HNF4alpha and negatively regulates gluconeogenic enzyme gene expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22449)
16. [Phenobarbital regulates nuclear expression of HNF-4alpha in mouse and rat hepatocytes independent of CAR and PXR](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22449)
17. [Hepatocyte nuclear factor (HNF)-4α triggers formation of functional tight junctions and establishment of polarized epithelial morphology in F9 embryonal carcinoma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22449)
18. [HNF4α contributes to glucose formation in aged rat hepatocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22449)
19. [Activation of p21CIP1/WAF1 gene expression and inhibition of cell proliferation by overexpression of hepatocyte nuclear factor-4alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22449)
20. [Hepatocyte nuclear factor-4alpha and -1 small interfering RNA inhibits hepatocyte differentiation induced by extracellular matrix](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22449)
21. [Hepatocyte nuclear factor (HNF)-4alpha induces expression of endothelial Fas ligand (FasL) to prevent cancer cell transmigration: a novel defense mechanism of endothelium against cancer metastasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22449)
22. [Fasting induces basolateral uptake transporters of the SLC family in the liver via HNF4alpha and PGC1alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22449)
23. [Lipopolysaccharide results in a marked decrease in hepatocyte nuclear factor 4α in rat liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22449)
24. [The nuclear receptor hepatocyte nuclear factor 4alpha acts as a morphogen to induce the formation of microvilli](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22449)
25. [Signalling cross-talk between hepatocyte nuclear factor 4alpha and growth-hormone-activated STAT5b](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22449)
26. [[Expression of hepatocyte-enriched transcriptional factors during the differentiation of bone marrow mesenchymal stem cell-derived hepatocytes].](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22449)
27. [Prenatal programming of hepatocyte nuclear factor 4alpha in the rat: A key mechanism in the 'foetal origins of hyperglycaemia'?](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22449)
28. ensembl Release 106