# Hepatic nuclear factor 4, alpha

> mammalian protein found in Mus musculus

**Wikidata**: [Q21496454](https://www.wikidata.org/wiki/Q21496454)  
**Source**: https://4ort.xyz/entity/hepatic-nuclear-factor-4-alpha


## References

1. UniProt
2. Q20641742
3. [Intestinal apolipoprotein AI gene transcription is regulated by multiple distinct DNA elements and is synergistically activated by the orphan nuclear receptor, hepatocyte nuclear factor 4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698)
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698)
5. [Plasticity and expanding complexity of the hepatic transcription factor network during liver development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698)
6. [Hepatocyte nuclear factors 1alpha and 4alpha control expression of proline oxidase in adult liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698)
7. [The fetoprotein transcription factor (FTF) gene is essential to embryogenesis and cholesterol homeostasis and is regulated by a DR4 element](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698)
8. [In vivo role of the HNF4alpha AF-1 activation domain revealed by exon swapping](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698)
9. [The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698)
10. [Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49698&geneProductId=UniProtKB:P49698)
11. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49698&geneProductId=UniProtKB:P49698)
12. [Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698)
13. [The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698)
14. [Functional interaction of hepatic nuclear factor-4 and peroxisome proliferator-activated receptor-gamma coactivator 1alpha in CYP7A1 regulation is inhibited by a key lipogenic activator, sterol regulatory element-binding protein-1c](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698)
15. [Identification and characterization of a 315-base pair enhancer, located more than 55 kilobases 5' of the apolipoprotein B gene, that confers expression in the intestine](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49698&geneProductId=UniProtKB:P49698)
16. [Anks4b, a novel target of HNF4α protein, interacts with GRP78 protein and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic β-cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698)
17. [The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/forkhead proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698)
18. [Identification and characterization of a 315-base pair enhancer, located more than 55 kilobases 5' of the apolipoprotein B gene, that confers expression in the intestine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698)
19. [Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698)
20. [Transcriptional regulation by HNF-4 of the steroid 15α-hydroxylase P450 (Cyp2a-4) gene in mouse liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698)
21. [An alternative splice variant of the tissue specific transcription factor HNF4 predominates in undifferentiated murine cell types](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698)
22. [Suppression of C/EBPalpha expression in periportal hepatoblasts may stimulate biliary cell differentiation through increased Hnf6 and Hnf1b expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698)
23. [Insulin-like growth factor 1 receptor signaling regulates skin development and inhibits skin keratinocyte differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698)
24. [GATA6 is essential for embryonic development of the liver but dispensable for early heart formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698)
25. [Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698)
26. [The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698)
27. [The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49698&geneProductId=UniProtKB:P49698)
28. [ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698)
29. [Characterization of three growth hormone-responsive transcription factors preferentially expressed in adult female liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698)
30. [Small Heterodimer Partner Regulates Circadian Cytochromes p450 and Drug-Induced Hepatotoxicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698)
31. [Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698)
32. [Hepatocyte nuclear factor-4alpha plays pivotal roles in the regulation of mouse carboxylesterase 2 gene transcription in mouse liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698)
33. [Murine gastrulation requires HNF-4 regulated gene expression in the visceral endoderm: tetraploid rescue of Hnf-4(-/-) embryos](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698)
34. [Nuclear receptor HNF4A transrepresses CLOCK:BMAL1 and modulates tissue-specific circadian networks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49698)
35. ensembl Release 106