# Heparanase

> mammalian protein found in Homo sapiens

**Wikidata**: [Q909646](https://www.wikidata.org/wiki/Q909646)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Heparanase)  
**Source**: https://4ort.xyz/entity/heparanase


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9Y251)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [Heterodimer formation is essential for heparanase enzymatic activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y251)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y251&geneProductId=UniProtKB:Q9Y251)
7. [Structural recognition by recombinant human heparanase that plays critical roles in tumor metastasis. Hierarchical sulfate groups with different effects and the essential target disulfated trisaccharide sequence](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y251&geneProductId=UniProtKB:Q9Y251)
8. [Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y251)
9. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y251)
10. [Heparanase uptake is mediated by cell membrane heparan sulfate proteoglycans](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y251)
11. [Heparanase enhances the generation of activated factor X in the presence of tissue factor and activated factor VII](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y251)
12. [Histidine-rich glycoprotein binds heparanase and regulates its enzymatic activity and cell surface interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y251)
13. [Structural recognition by recombinant human heparanase that plays critical roles in tumor metastasis. Hierarchical sulfate groups with different effects and the essential target disulfated trisaccharide sequence](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y251)
14. [Processing and activation of latent heparanase occurs in lysosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y251)
15. [Heparanase in primary human osteoblasts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y251)
16. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y251)
17. [Heparanase induces endothelial cell migration via protein kinase B/Akt activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y251)
18. [Heparanase 1: a key participant of inner root sheath differentiation program and hair follicle homeostasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y251)
19. [Human heparanase. Purification, characterization, cloning, and expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y251)
20. [Heparanase induces vascular endothelial growth factor expression: correlation with p38 phosphorylation levels and Src activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y251)
21. [Heparanase mediates cell adhesion independent of its enzymatic activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y251&geneProductId=UniProtKB:Q9Y251)
22. [Heparanase mediates cell adhesion independent of its enzymatic activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y251)
23. Ensembl Release 99
24. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)