# Heparan sulfate proteoglycan 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q2071346](https://www.wikidata.org/wiki/Q2071346)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Perlecan)  
**Source**: https://4ort.xyz/entity/heparan-sulfate-proteoglycan-2


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P98160)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160)
5. [The type XIII collagen ectodomain is a 150-nm rod and capable of binding to fibronectin, nidogen-2, perlecan, and heparin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160)
6. [Endorepellin, the angiostatic module of perlecan, interacts with both the α2β1 integrin and vascular endothelial growth factor receptor 2 (VEGFR2): a dual receptor antagonism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160)
7. [Endorepellin laminin-like globular 1/2 domains bind Ig3-5 of vascular endothelial growth factor (VEGF) receptor 2 and block pro-angiogenic signaling by VEGFA in endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160)
8. [Perlecan protein core interacts with extracellular matrix protein 1 (ECM1), a glycoprotein involved in bone formation and angiogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160)
9. [Heparan Sulphate Proteoglycan and the Low-Density Lipoprotein Receptor-Related Protein 1 Constitute Major Pathways for Neuronal Amyloid-β Uptake](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160)
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P98160&geneProductId=UniProtKB:P98160)
11. [Comprehensive proteomic characterization of stem cell-derived extracellular matrices](http://www.ebi.ac.uk/QuickGO/annotations?protein=P98160&geneProductId=UniProtKB:P98160)
12. [Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P98160&geneProductId=UniProtKB:P98160)
13. [SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers](http://www.ebi.ac.uk/QuickGO/annotations?protein=P98160&geneProductId=UniProtKB:P98160)
14. [Proteomics characterization of extracellular space components in the human aorta](http://www.ebi.ac.uk/QuickGO/annotations?protein=P98160&geneProductId=UniProtKB:P98160)
15. [Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P98160&geneProductId=UniProtKB:P98160)
16. [Proteomics characterization of extracellular space components in the human aorta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160)
17. [Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160)
18. [SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160)
19. [Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160)
20. [Comprehensive proteomic characterization of stem cell-derived extracellular matrices](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160)
21. [Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160)
22. [GOA](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P98160)
23. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P98160)
24. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P98160)
25. [Proteomic analysis of podocyte exosome-enriched fraction from normal human urine](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P98160)
26. [Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P98160)
27. [Protein profile of exosomes from trabecular meshwork cells](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P98160)
28. [Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P98160)
29. [Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P98160)
30. [SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P98160)
31. [Proteomics characterization of extracellular space components in the human aorta](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P98160)
32. [Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P98160)
33. [Human colostrum: identification of minor proteins in the aqueous phase by proteomics](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P98160)
34. [Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160)
35. [Perlecan and basement membrane-chondroitin sulfate proteoglycan (bamacan) are two basement membrane chondroitin/dermatan sulfate proteoglycans in the Engelbreth-Holm-Swarm tumor matrix](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160)
36. [Perlecan domain V inhibits α2 integrin-mediated amyloid-β neurotoxicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160)
37. [Human colostrum: identification of minor proteins in the aqueous phase by proteomics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160)
38. [Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160)
39. [Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160)
40. [Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160)
41. [Protein profile of exosomes from trabecular meshwork cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160)
42. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160)
43. [Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160)
44. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160)
45. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160)
46. Ensembl Release 99
47. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)