# Heme oxygenase 1

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28558146](https://www.wikidata.org/wiki/Q28558146)  
**Source**: https://4ort.xyz/entity/heme-oxygenase-1-q28558146


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P06762)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762)
5. [Leydig cell-derived heme oxygenase-1 regulates apoptosis of premeiotic germ cells in response to stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762)
6. [Cloning and expression of cDNA for rat heme oxygenase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762)
7. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762)
8. [Heme oxygenase inhibitor restores arteriolar nitric oxide function in dahl rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762)
9. [Caveolae compartmentalization of heme oxygenase-1 in endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762)
10. [Involvement of NADPH in the interaction between heme oxygenase-1 and cytochrome P450 reductase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762)
11. [Crystal structure of rat apo-heme oxygenase-1 (HO-1): mechanism of heme binding in HO-1 inferred from structural comparison of the apo and heme complex forms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762)
12. [Immunocytochemical localization and expression of heme oxygenase-1 in primary astroglial cell cultures during differentiation: effect of glutamate](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762)
13. [Heme oxygenase-1 protein localizes to the nucleus and activates transcription factors important in oxidative stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762)
14. [Facilitated angiogenesis induced by heme oxygenase-1 gene transfer in a rat model of hindlimb ischemia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762)
15. [Regulation of heme oxygenase-1 by nitric oxide during hepatopulmonary syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762)
16. [Hypoxia inducible factor-1 alpha correlates the expression of heme oxygenase 1 gene in pulmonary arteries of rat with hypoxia-induced pulmonary hypertension](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762)
17. [Resistance to nitric oxide-induced necrosis in heme oxygenase-1 overexpressing pulmonary epithelial cells associated with decreased lipid peroxidation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762)
18. [Selective regulation of blood pressure by heme oxygenase-1 in hypertension](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762)
19. [Heme oxygenase-1 inhibits rat and human breast cancer cell proliferation: mutual cross inhibition with indoleamine 2,3-dioxygenase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762)
20. [Heme oxygenase 1 mediates the immunomodulatory and antiapoptotic effects of interleukin 13 gene therapy in vivo and in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762)
21. [Effects of 1alpha,25 dihydroxyvitamin D3 on the expression of HO-1 and GFAP in glial cells of the photothrombotically lesioned cerebral cortex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762)
22. [Heme oxygenase-1 inhibits cytokine production by activated mast cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762)
23. [Mitogen-activated protein kinases regulate HO-1 gene transcription after ischemia-reperfusion lung injury](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762)
24. [Neuroprotective role of heme-oxygenase 1 against iodoacetate-induced toxicity in rat cerebellar granule neurons: Role of bilirubin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762)
25. [Mechanism of salutary effects of estradiol on organ function after trauma-hemorrhage: upregulation of heme oxygenase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762)
26. [Over-expression of HO-1 on mesenchymal stem cells promotes angiogenesis and improves myocardial function in infarcted myocardium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762)
27. [Aprotinin Inhibits Vascular Smooth Muscle Cell Inflammation and Proliferation via Induction of HO-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762)
28. [Regulation of heme oxygenase 1 expression by miR-27b with stem cell therapy for liver regeneration in rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762)
29. [The role of heme oxygenase 1 in hydrogen peroxide induced apoptosis and mitochondrial trans membrane potential change in rat primary type II alveolar epithelium cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762)
30. [Naringenin inhibits TNF-α induced VSMC proliferation and migration via induction of HO-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P06762)
31. ensembl Release 106