HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
type: Thing
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P361
  value: HECT, E3 ligase catalytic domain
additional property: PropertyValue
  property ID: P361
  value: WW domain superfamily
additional property: PropertyValue
  property ID: P361
  value: C2 domain superfamily
additional property: PropertyValue
  property ID: P527
  value: C2 domain
additional property: PropertyValue
  property ID: P527
  value: E3 ubiquitin-protein ligase HECW1/2, N-terminal
additional property: PropertyValue
  property ID: P527
  value: WW domain
additional property: PropertyValue
  property ID: P637
  value: NP_001273988
additional property: PropertyValue
  property ID: P637
  value: NP_055867
additional property: PropertyValue
  property ID: P637
  value: XP_005249722
additional property: PropertyValue
  property ID: P638
  value: 3L4H
additional property: PropertyValue
  property ID: P680
  value: transferase activity
additional property: PropertyValue
  property ID: P680
  value: ubiquitin-protein transferase activity
additional property: PropertyValue
  property ID: P680
  value: ubiquitin protein ligase activity
additional property: PropertyValue
  property ID: P681
  value: cytosol
additional property: PropertyValue
  property ID: P681
  value: cytoplasm
additional property: PropertyValue
  property ID: P682
  value: negative regulation of canonical Wnt signaling pathway
additional property: PropertyValue
  property ID: P682
  value: protein ubiquitination
additional property: PropertyValue
  property ID: P682
  value: proteasome-mediated ubiquitin-dependent protein catabolic process
additional property: PropertyValue
  property ID: P702
  value: HECW1
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000379228
additional property: PropertyValue
  property ID: P705
  value: ENSP00000407774
additional property: PropertyValue
  property ID: P705
  value: ENSP00000413336
confidence:
  popularity graph score:
    score: 0.001
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 7
      unique citations norm: 0.003
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 7
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: Q76N89
    source count: 1
    confidence: 0.2
  P361:
    value: Q41797130
    source count: 1
    confidence: 0.2
    value label: HECT, E3 ligase catalytic domain
  P361:
    value: Q41797163
    source count: 1
    confidence: 0.2
    value label: WW domain superfamily
  P361:
    value: Q41797043
    source count: 1
    confidence: 0.2
    value label: C2 domain superfamily
  P361:
    value: Q83146753
    source count: 1
    confidence: 0.2
    value label: E3 ubiquitin-protein ligase HECW1/2, N-terminal domain, protein family
  P361:
    value: Q83135800
    source count: 1
    confidence: 0.2
    value label: HECT domain, protein family
  P527:
    value: Q24774737
    source count: 1
    confidence: 0.2
    value label: C2 domain
  P527:
    value: Q24779343
    source count: 1
    confidence: 0.2
    value label: E3 ubiquitin-protein ligase HECW1/2, N-terminal
  P527:
    value: Q24726881
    source count: 1
    confidence: 0.2
    value label: WW domain
  P527:
    value: Q24726575
    source count: 1
    confidence: 0.2
    value label: HECT domain
  P527:
    value: Q54460336
    source count: 1
    confidence: 0.2
    value label: E3 ubiquitin-protein ligase HECW, C2 domain
  P637:
    value: NP_001273988
    source count: 1
    confidence: 0.2
  P637:
    value: NP_055867
    source count: 1
    confidence: 0.2
  P637:
    value: XP_005249722
    source count: 1
    confidence: 0.2
  P637:
    value: XP_006715733
    source count: 1
    confidence: 0.2
  P637:
    value: XP_006715734
    source count: 1
    confidence: 0.2
  P638:
    value: 3L4H
    source count: 1
    confidence: 0.2
  P680:
    value: Q14840131
    source count: 1
    confidence: 0.2
    value label: transferase activity
  P680:
    value: Q14860441
    source count: 1
    confidence: 0.2
    value label: ubiquitin-protein transferase activity
  P680:
    value: Q21095456
    source count: 2
    confidence: 0.4
    value label: ubiquitin protein ligase activity
  P681:
    value: Q220599
    source count: 2
    confidence: 0.4
    value label: cytosol
  P681:
    value: Q79899
    source count: 2
    confidence: 0.4
    value label: cytoplasm
  P682:
    value: Q14860027
    source count: 1
    confidence: 0.2
    value label: negative regulation of canonical Wnt signaling pathway

value: Q3547638
source count: 1
confidence: 0.2
value label: protein ubiquitination

value: Q15323482
source count: 1
confidence: 0.2
value label: proteasome-mediated ubiquitin-dependent protein catabolic process

value: Q14863376
source count: 1
confidence: 0.2
value label: protein polyubiquitination

value: Q14864233
source count: 1
confidence: 0.2
value label: ubiquitin-dependent protein catabolic process

value: Q18036702
source count: 1
confidence: 0.2
value label: HECW1

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000379228
source count: 1
confidence: 0.2

value: ENSP00000407774
source count: 1
confidence: 0.2

value: ENSP00000413336
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-04-08

source: GOA
stated in qid: Q28018111
retrieved: 2018-02-27

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2019-11-13

source: Q20641742
stated in qid: Q20641742
retrieved: 2020-05-30

source: Ensembl Release 99
stated in qid: Q83867711

wikidata id: Q21118238
domain: protein
level: standard
html url: https://4ort.xyz/entity/hect-c2-and-ww-domain-containing-e3-ubiquitin-protein-ligase-1-q21118238
markdown url: https://4ort.xyz/entity/hect-c2-and-ww-domain-containing-e3-ubiquitin-protein-ligase-1-q21118238.md
facts url summary: https://4ort.xyz/entity/hect-c2-and-ww-domain-containing-e3-ubiquitin-protein-ligase-1-q21118238/facts.json
facts url standard: https://4ort.xyz/entity/hect-c2-and-ww-domain-containing-e3-ubiquitin-protein-ligase-1-q21118238/facts.json
facts url full: https://4ort.xyz/entity/hect-c2-and-ww-domain-containing-e3-ubiquitin-protein-ligase-1-q21118238/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-10T02:23:23.939585Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T15:25:56.647217+00:00Z