HECT and RLD domain containing E3 ubiquitin protein ligase 2
type: Thing
description: mammalian protein found in Mus musculus
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P279
  value: protein
additional property: PropertyValue
  property ID: P361
  value: HECT, E3 ligase catalytic domain
additional property: PropertyValue
  property ID: P361
  value: cytochrome b5-like heme/steroid binding domain superfamily
additional property: PropertyValue
  property ID: P361
  value: Ribosomal protein L2, domain 2
additional property: PropertyValue
  property ID: P527
  value: Beta-propeller repeat TECPR
additional property: PropertyValue
  property ID: P527
  value: Regulator of chromosome condensation, RCC1
additional property: PropertyValue
  property ID: P527
  value: Mib-herc2
additional property: PropertyValue
  property ID: P637
  value: NP_034548
additional property: PropertyValue
  property ID: P637
  value: XP_006540700
additional property: PropertyValue
  property ID: P637
  value: XP_006540702
additional property: PropertyValue
  property ID: P680
  value: zinc ion binding
additional property: PropertyValue
  property ID: P680
  value: metal ion binding
additional property: PropertyValue
  property ID: P680
  value: SUMO binding
additional property: PropertyValue
  property ID: P681
  value: cytoplasm
additional property: PropertyValue
  property ID: P681
  value: mitochondrial inner membrane
additional property: PropertyValue
  property ID: P681
  value: centriole
additional property: PropertyValue
  property ID: P682
  value: cellular response to DNA damage stimulus
additional property: PropertyValue
  property ID: P682
  value: protein ubiquitination
additional property: PropertyValue
  property ID: P682
  value: spermatogenesis
additional property: PropertyValue
  property ID: P702
  value: Herc2
additional property: PropertyValue
  property ID: P703
  value: house mouse
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000075579
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000131573
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000145997
confidence:
  popularity graph score:
    score: 0.002
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 11
      unique citations norm: 0.004
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 11
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P279:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: Q4U2R1
    source count: 1
    confidence: 0.2
  P361:
    value: Q41797130
    source count: 1
    confidence: 0.2
    value label: HECT, E3 ligase catalytic domain
  P361:
    value: Q41797515
    source count: 1
    confidence: 0.2
    value label: cytochrome b5-like heme/steroid binding domain superfamily
  P361:
    value: Q24783072
    source count: 1
    confidence: 0.2
    value label: Ribosomal protein L2, domain 2
  P361:
    value: Q24780736
    source count: 1
    confidence: 0.2
    value label: Galactose-binding-like domain superfamily
  P361:
    value: Q24726462
    source count: 1
    confidence: 0.2
    value label: Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
  P527:
    value: Q24775299
    source count: 1
    confidence: 0.2
    value label: Beta-propeller repeat TECPR
  P527:
    value: Q24779063
    source count: 1
    confidence: 0.2
    value label: Regulator of chromosome condensation, RCC1
  P527:
    value: Q24740734
    source count: 1
    confidence: 0.2
    value label: Mib-herc2
  P527:
    value: Q24721905
    source count: 1
    confidence: 0.2
    value label: cytochrome b5-like heme/steroid binding domain
  P527:
    value: Q24776809
    source count: 1
    confidence: 0.2
    value label: CPH domain
  P637:
    value: NP_034548
    source count: 1
    confidence: 0.2
  P637:
    value: XP_006540700
    source count: 1
    confidence: 0.2
  P637:
    value: XP_006540702
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001347009
    source count: 1
    confidence: 0.2
  P680:
    value: Q14633865
    source count: 1
    confidence: 0.2
    value label: zinc ion binding
  P680:
    value: Q13667380
    source count: 2
    confidence: 0.4
    value label: metal ion binding
  P680:
    value: Q21106969
    source count: 3
    confidence: 0.6
    value label: SUMO binding
  P680:
    value: Q14633869
    source count: 2
    confidence: 0.4
    value label: ubiquitin protein ligase binding
  P680:
    value: Q14860441
    source count: 4
    confidence: 0.8
    value label: ubiquitin-protein transferase activity
  P681:
    value: Q79899
    source count: 4
    confidence: 0.8
    value label: cytoplasm

value: Q14330614
source count: 1
confidence: 0.2
value label: mitochondrial inner membrane

value: Q178355
source count: 1
confidence: 0.2
value label: centriole

value: Q154626
source count: 1
confidence: 0.2
value label: cytoskeleton

value: Q40260
source count: 5
confidence: 1.0
value label: nucleus

value: Q14818018
source count: 4
confidence: 0.8
value label: cellular response to DNA damage stimulus

value: Q3547638
source count: 5
confidence: 1.0
value label: protein ubiquitination

value: Q36961
source count: 1
confidence: 0.2
value label: spermatogenesis

value: Q210538
source count: 1
confidence: 0.2
value label: DNA repair

value: Q15323482
source count: 1
confidence: 0.2
value label: proteasome-mediated ubiquitin-dependent protein catabolic process

value: Q18251175
source count: 1
confidence: 0.2
value label: Herc2

value: Q83310
source count: 1
confidence: 0.2
value label: house mouse

value: ENSMUSP00000075579
source count: 1
confidence: 0.2

value: ENSMUSP00000131573
source count: 1
confidence: 0.2

value: ENSMUSP00000145997
source count: 1
confidence: 0.2

value: ENSMUSP00000145560
source count: 1
confidence: 0.2

value: ENSMUSP00000145771
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-02-14

source: GOA
stated in qid: Q28018111
retrieved: 2018-01-31

source: Proteomic analysis of the mouse liver mitochondrial inner membrane
stated in qid: Q28587359
retrieved: 2018-01-31

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-02-14

source: Proteomic analysis of the mouse liver mitochondrial inner membrane
stated in qid: Q28587359
retrieved: 2019-02-14

source: Abnormal spermiogenesis in two pink-eyed sterile mutants in the mouse
stated in qid: Q28592739
retrieved: 2019-02-14

source: Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling.
stated in qid: Q50236752
retrieved: 2019-02-14

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2022-05-25

source: Q20641742
stated in qid: Q20641742
retrieved: 2022-03-20

source: ensembl Release 106
stated in qid: Q111699881

wikidata id: Q21984080
domain: protein
level: standard
html url: https://4ort.xyz/entity/hect-and-rld-domain-containing-e3-ubiquitin-protein-ligase-2-q21984080
markdown url: https://4ort.xyz/entity/hect-and-rld-domain-containing-e3-ubiquitin-protein-ligase-2-q21984080.md
facts url summary: https://4ort.xyz/entity/hect-and-rld-domain-containing-e3-ubiquitin-protein-ligase-2-q21984080/facts.json
facts url standard: https://4ort.xyz/entity/hect-and-rld-domain-containing-e3-ubiquitin-protein-ligase-2-q21984080/facts.json
facts url full: https://4ort.xyz/entity/hect-and-rld-domain-containing-e3-ubiquitin-protein-ligase-2-q21984080/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-06T11:50:44.051929Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T15:12:24.892497+00:00Z