# Heat shock protein family A (Hsp70) member 1B

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21119777](https://www.wikidata.org/wiki/Q21119777)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/HSPA1B)  
**Source**: https://4ort.xyz/entity/heat-shock-protein-family-a-hsp70-member-1b


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P0DMV8)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8)
5. [HDJC9, a novel human type C DnaJ/HSP40 member interacts with and cochaperones HSP70 through the J domain](http://www.ebi.ac.uk/QuickGO/annotations?protein=P0DMV8&geneProductId=UniProtKB:P0DMV8)
6. [The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities](http://www.ebi.ac.uk/QuickGO/annotations?protein=P0DMV8&geneProductId=UniProtKB:P0DMV8)
7. [Identification and Characterization of a Novel Human Methyltransferase Modulating Hsp70 Protein Function through Lysine Methylation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P0DMV8&geneProductId=UniProtKB:P0DMV8)
8. [The Molecular Chaperone HSP70 Binds to and Stabilizes NOD2, an Important Protein Involved in Crohn Disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8)
9. [RING finger protein RNF207, a novel regulator of cardiac excitation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8)
10. [Histone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8)
11. [BAG5 inhibits parkin and enhances dopaminergic neuron degeneration](http://www.ebi.ac.uk/QuickGO/annotations?protein=P0DMV8&geneProductId=UniProtKB:P0DMV8)
12. [CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8)
13. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P0DMV8&geneProductId=UniProtKB:P0DMV8)
14. [Identification and Characterization of a Novel Human Methyltransferase Modulating Hsp70 Protein Function through Lysine Methylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8)
15. [CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P0DMV8&geneProductId=UniProtKB:P0DMV8)
16. [ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8)
17. [Binding of Human Nucleotide Exchange Factors to Heat Shock Protein 70 (Hsp70) Generates Functionally Distinct Complexes in Vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8)
18. [Interactions between Hsp70 and the hydrophobic core of alpha-synuclein inhibit fibril assembly](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8)
19. [A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8)
20. [The C-terminal Helices of Heat Shock Protein 70 Are Essential for J-domain Binding and ATPase Activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8)
21. [Hsp70 and Hsp90 oppositely regulate TGF-β signaling through CHIP/Stub1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8)
22. [Evidence for a role of Hsp 70 in the regulation of the heat shock response in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8)
23. [A novel nuclear DnaJ protein, DNAJC8, can suppress the formation of spinocerebellar ataxia 3 polyglutamine aggregation in a J-domain independent manner.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8)
24. [HSP70 regulates the function of mitotic centrosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8)
25. [Heat shock protein 70 inhibits alpha-synuclein fibril formation via preferential binding to prefibrillar species](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8)
26. [ChChd3, an Inner Mitochondrial Membrane Protein, Is Essential for Maintaining Crista Integrity and Mitochondrial Function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8)
27. [Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8)
28. [Nucleophosmin (NPM1/B23) interacts with activating transcription factor 5 (ATF5) protein and promotes proteasome- and caspase-dependent ATF5 degradation in hepatocellular carcinoma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8)
29. [Molecularchaperones as HSF1-specific transcriptional repressors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8)
30. [HSP72 protects cells from ER stress-induced apoptosis via enhancement of IRE1alpha-XBP1 signaling through a physical interaction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8)
31. [Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8)
32. [HSP70 sequestration by free α-globin promotes ineffective erythropoiesis in β-thalassaemia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8)
33. [70-kDa heat shock proteins: specific interactions with HLA-DR molecules and their peptide fragments](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8)
34. [Mutations in the substrate binding site of human heat‐shock protein 70 indicate specific interaction with HLA‐DR outside the peptide binding groove](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8)
35. [Human respiratory syncytial virus N, P and M protein interactions in HEK-293T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8)
36. [Discovery of multiple interacting partners of gankyrin, a proteasomal chaperone and an oncoprotein--evidence for a common hot spot site at the interface and its functional relevance.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8)
37. [Structure and function of Hip, an attenuator of the Hsp70 chaperone cycle](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8)
38. [Regulation of Hsp90 client proteins by a Cullin5-RING E3 ubiquitin ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8)
39. [The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8)
40. [The C-terminal BAG domain of BAG5 induces conformational changes of the Hsp70 nucleotide-binding domain for ADP-ATP exchange](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8)
41. [BAG5 inhibits parkin and enhances dopaminergic neuron degeneration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8)
42. [Cellular cofactors affecting hepatitis C virus infection and replication](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8)
43. [Molecularchaperones as HSF1-specific transcriptional repressors](http://www.ebi.ac.uk/QuickGO/annotations?protein=P0DMV8&geneProductId=UniProtKB:P0DMV8)
44. [E-cadherin interactome complexity and robustness resolved by quantitative proteomics](http://www.ebi.ac.uk/QuickGO/annotations?protein=P0DMV8&geneProductId=UniProtKB:P0DMV8)
45. [The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts](http://www.ebi.ac.uk/QuickGO/annotations?protein=P0DMV8&geneProductId=UniProtKB:P0DMV8)
46. [Insights into RNA biology from an atlas of mammalian mRNA-binding proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=P0DMV8&geneProductId=UniProtKB:P0DMV8)
47. [Intrinsically disordered proteins as molecular shields](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8)
48. [Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8)
49. [Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P0DMV8&geneProductId=UniProtKB:P0DMV8)
50. [HSP90, HSP70, and GAPDH Directly Interact with the Cytoplasmic Domain of Macrophage Scavenger Receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0DMV8)