HCK proto-oncogene, Src family tyrosine kinase
type: Thing
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P352
  value: P08631
additional property: PropertyValue
  property ID: P361
  value: SH3-like domain superfamily
additional property: PropertyValue
  property ID: P361
  value: Protein kinase-like domain superfamily
additional property: PropertyValue
  property ID: P361
  value: SH2 domain superfamily
additional property: PropertyValue
  property ID: P486
  value: D051572
additional property: PropertyValue
  property ID: P527
  value: tyrosine-protein kinase, active site
additional property: PropertyValue
  property ID: P527
  value: SH3 domain
additional property: PropertyValue
  property ID: P527
  value: protein kinase, ATP binding site
additional property: PropertyValue
  property ID: P637
  value: NP_001165600
additional property: PropertyValue
  property ID: P637
  value: NP_001165601
additional property: PropertyValue
  property ID: P637
  value: NP_001165602
additional property: PropertyValue
  property ID: P638
  value: 1AD5
additional property: PropertyValue
  property ID: P638
  value: 1BU1
additional property: PropertyValue
  property ID: P638
  value: 1QCF
additional property: PropertyValue
  property ID: P672
  value: D08.811.913.696.620.682.725.800.590
additional property: PropertyValue
  property ID: P672
  value: D12.776.476.568.800.590
additional property: PropertyValue
  property ID: P672
  value: D12.776.624.664.700.181
additional property: PropertyValue
  property ID: P680
  value: transferase activity
additional property: PropertyValue
  property ID: P680
  value: nucleotide binding
additional property: PropertyValue
  property ID: P680
  value: protein kinase activity
additional property: PropertyValue
  property ID: P681
  value: cytoplasm
additional property: PropertyValue
  property ID: P681
  value: cytosol
additional property: PropertyValue
  property ID: P681
  value: Golgi apparatus
additional property: PropertyValue
  property ID: P682
  value: cell differentiation
additional property: PropertyValue
  property ID: P682
  value: leukocyte migration involved in immune response
additional property: PropertyValue
  property ID: P682
  value: positive regulation of actin filament polymerization
additional property: PropertyValue
  property ID: P702
  value: HCK
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000427757
confidence:
  popularity graph score:
    score: 0.006
    score pct: 1
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 42
      unique citations norm: 0.017
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 42
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: P08631
    source count: 1
    confidence: 0.2
  P361:
    value: Q41797170
    source count: 1
    confidence: 0.2
    value label: SH3-like domain superfamily
  P361:
    value: Q24726164
    source count: 1
    confidence: 0.2
    value label: Protein kinase-like domain superfamily
  P361:
    value: Q41797956
    source count: 1
    confidence: 0.2
    value label: SH2 domain superfamily
  P361:
    value: Q50261758
    source count: 0
    confidence: 0.0
    value label: Src family kinases (SFKs) [cytosol]
  P361:
    value: Q83137014
    source count: 1
    confidence: 0.2
    value label: Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family
  P486:
    value: D051572
    source count: 0
    confidence: 0.0
  P527:
    value: Q24738472
    source count: 1
    confidence: 0.2
    value label: tyrosine-protein kinase, active site
  P527:
    value: Q24771787
    source count: 1
    confidence: 0.2
    value label: SH3 domain
  P527:
    value: Q24769051
    source count: 1
    confidence: 0.2
    value label: protein kinase, ATP binding site
  P527:
    value: Q24768234
    source count: 1
    confidence: 0.2
    value label: protein kinase domain
  P527:
    value: Q24719835
    source count: 1
    confidence: 0.2
    value label: tyrosine-protein kinase, catalytic domain
  P637:
    value: NP_001165600
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001165601
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001165602
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001165603
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001165604
    source count: 1
    confidence: 0.2
  P638:
    value: 1AD5
    source count: 1
    confidence: 0.2
  P638:
    value: 1BU1
    source count: 1
    confidence: 0.2

value: 1QCF
source count: 1
confidence: 0.2

value: 2C0I
source count: 1
confidence: 0.2

value: 2C0O
source count: 1
confidence: 0.2

value: D08.811.913.696.620.682.725.800.590
source count: 0
confidence: 0.0

value: D12.776.476.568.800.590
source count: 0
confidence: 0.0

value: D12.776.624.664.700.181
source count: 0
confidence: 0.0

value: Q14840131
source count: 1
confidence: 0.2
value label: transferase activity

value: Q14860365
source count: 1
confidence: 0.2
value label: nucleotide binding

value: Q14820641
source count: 1
confidence: 0.2
value label: protein kinase activity

value: Q14873985
source count: 2
confidence: 0.4
value label: non-membrane spanning protein tyrosine kinase activity

value: Q14863082
source count: 1
confidence: 0.2
value label: kinase activity

value: Q79899
source count: 1
confidence: 0.2
value label: cytoplasm

value: Q220599
source count: 2
confidence: 0.4
value label: cytosol

value: Q83181
source count: 1
confidence: 0.2
value label: Golgi apparatus

value: Q14353100
source count: 1
confidence: 0.2
value label: cell projection

value: Q14349455
source count: 1
confidence: 0.2
value label: membrane

value: Q210861
source count: 1
confidence: 0.2
value label: cell differentiation

value: Q21112440
source count: 1
confidence: 0.2
value label: leukocyte migration involved in immune response

value: Q14863108
source count: 1
confidence: 0.2
value label: positive regulation of actin filament polymerization

value: Q14863968
source count: 1
confidence: 0.2
value label: Fc-gamma receptor signaling pathway involved in phagocytosis

value: Q242736
source count: 1
confidence: 0.2
value label: phosphorylation

value: Q18026836
source count: 1
confidence: 0.2
value label: HCK

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000427757
source count: 1
confidence: 0.2

value: ENSP00000429848
source count: 1
confidence: 0.2

value: ENSP00000441169
source count: 1
confidence: 0.2

value: ENSP00000486627
source count: 1
confidence: 0.2

value: ENSP00000262651
source count: 1
confidence: 0.2

value: C0286943
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-04-08

source: Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4
stated in qid: Q24313595
retrieved: 2019-04-08

source: Molecular characterization of WDCP, a novel fusion partner for the anaplastic lymphoma tyrosine kinase ALK
stated in qid: Q24308008
retrieved: 2019-04-08

source: Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1
stated in qid: Q24298086
retrieved: 2019-04-08

source: Further studies on hepatitis C virus NS5A-SH3 domain interactions: identification of residues critical for binding and implications for viral RNA replication and modulation of cell signalling
stated in qid: Q24298665
retrieved: 2019-04-08

source: Identification and biophysical assessment of the molecular recognition mechanisms between the human haemopoietic cell kinase Src homology domain 3 and ALG-2-interacting protein X
stated in qid: Q24293548
retrieved: 2019-04-08

source: Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases
stated in qid: Q24291999
retrieved: 2019-04-08

source: A quantitative protein interaction network for the ErbB receptors using protein microarrays
stated in qid: Q24293746
retrieved: 2019-04-08

source: A proteome-scale map of the human interactome network
stated in qid: Q24307146
retrieved: 2019-04-08

source: The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells
stated in qid: Q24292828
retrieved: 2019-04-08

source: Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis
stated in qid: Q24320165
retrieved: 2019-04-08

source: Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma
stated in qid: Q24316017
retrieved: 2019-04-08

source: Analysis of 5-lipoxygenase phosphorylation on molecular level by MALDI-MS
stated in qid: Q24298266
retrieved: 2019-04-08

source: Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome
stated in qid: Q24294625
retrieved: 2019-04-08

source: Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein
stated in qid: Q33307477
retrieved: 2019-04-08

source: Solution structure of a Hck SH3 domain ligand complex reveals novel interaction modes
stated in qid: Q24322075
retrieved: 2019-04-08

source: Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome
stated in qid: Q24299721
retrieved: 2019-04-08

source: The hepatitis C virus NS5A protein binds to members of the Src family of tyrosine kinases and regulates kinase activity
stated in qid: Q24313430
retrieved: 2019-04-08

source: The tyrosine kinase Hck is an inhibitor of HIV-1 replication counteracted by the viral vif protein
stated in qid: Q24291013
retrieved: 2019-04-08

source: Structural recognition mechanisms between human Src homology domain 3 (SH3) and ALG-2-interacting protein X (Alix)
stated in qid: Q24336937
retrieved: 2019-04-08

source: Src kinase Hck association with the WASp and mDia1 cytoskeletal regulators promotes chemoattractant-induced Hck membrane targeting and activation in neutrophils
stated in qid: Q24313888
retrieved: 2019-04-08

source: Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells
stated in qid: Q24299170
retrieved: 2018-11-07

source: The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase
stated in qid: Q22009088
retrieved: 2018-11-07

source: GOA
stated in qid: Q28018111
retrieved: 2018-11-07

source: Differential kinase requirements in human and mouse Fc-gamma receptor phagocytosis and endocytosis
stated in qid: Q28115947
retrieved: 2018-11-07

source: Differential involvement of Src family kinases in Fc gamma receptor-mediated phagocytosis
stated in qid: Q28115092
retrieved: 2018-11-07

source: Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1
stated in qid: Q28902456
retrieved: 2019-04-08

source: Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells
stated in qid: Q24299170
retrieved: 2019-04-08

source: The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase
stated in qid: Q22009088
retrieved: 2019-04-08

wikidata id: Q21113798
domain: protein
level: standard
html url: https://4ort.xyz/entity/hck-proto-oncogene-src-family-tyrosine-kinase-q21113798
markdown url: https://4ort.xyz/entity/hck-proto-oncogene-src-family-tyrosine-kinase-q21113798.md
facts url summary: https://4ort.xyz/entity/hck-proto-oncogene-src-family-tyrosine-kinase-q21113798/facts.json
facts url standard: https://4ort.xyz/entity/hck-proto-oncogene-src-family-tyrosine-kinase-q21113798/facts.json
facts url full: https://4ort.xyz/entity/hck-proto-oncogene-src-family-tyrosine-kinase-q21113798/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-11T22:28:36.044354Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T15:12:06.018882+00:00Z