# HCK proto-oncogene, Src family tyrosine kinase

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21113798](https://www.wikidata.org/wiki/Q21113798)  
**Source**: https://4ort.xyz/entity/hck-proto-oncogene-src-family-tyrosine-kinase-q21113798


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P08631)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631)
5. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631)
6. [Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631)
7. [Molecular characterization of WDCP, a novel fusion partner for the anaplastic lymphoma tyrosine kinase ALK](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631)
8. [Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631)
9. [Further studies on hepatitis C virus NS5A-SH3 domain interactions: identification of residues critical for binding and implications for viral RNA replication and modulation of cell signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631)
10. [Identification and biophysical assessment of the molecular recognition mechanisms between the human haemopoietic cell kinase Src homology domain 3 and ALG-2-interacting protein X](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631)
11. [Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631)
12. [A quantitative protein interaction network for the ErbB receptors using protein microarrays](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631)
13. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631)
14. [The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631)
15. [Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631)
16. [Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631)
17. [Analysis of 5-lipoxygenase phosphorylation on molecular level by MALDI-MS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631)
18. [Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631)
19. [Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631)
20. [Solution structure of a Hck SH3 domain ligand complex reveals novel interaction modes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631)
21. [Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631)
22. [The hepatitis C virus NS5A protein binds to members of the Src family of tyrosine kinases and regulates kinase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631)
23. [The tyrosine kinase Hck is an inhibitor of HIV-1 replication counteracted by the viral vif protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631)
24. [Structural recognition mechanisms between human Src homology domain 3 (SH3) and ALG-2-interacting protein X (Alix)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631)
25. [Src kinase Hck association with the WASp and mDia1 cytoskeletal regulators promotes chemoattractant-induced Hck membrane targeting and activation in neutrophils](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631)
26. [Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08631&geneProductId=UniProtKB:P08631)
27. [The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08631&geneProductId=UniProtKB:P08631)
28. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08631&geneProductId=UniProtKB:P08631)
29. [Differential kinase requirements in human and mouse Fc-gamma receptor phagocytosis and endocytosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08631&geneProductId=UniProtKB:P08631)
30. [Differential involvement of Src family kinases in Fc gamma receptor-mediated phagocytosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08631&geneProductId=UniProtKB:P08631)
31. [Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631)
32. [Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631)
33. [The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631)
34. [p59Hck isoform induces F-actin reorganization to form protrusions of the plasma membrane in a Cdc42- and Rac-dependent manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631)
35. [p59Hck isoform induces F-actin reorganization to form protrusions of the plasma membrane in a Cdc42- and Rac-dependent manner](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08631&geneProductId=UniProtKB:P08631)
36. [Activation of the lysosome-associated p61Hck isoform triggers the biogenesis of podosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631)
37. [Myristoylation and differential palmitoylation of the HCK protein-tyrosine kinases govern their attachment to membranes and association with caveolae](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631)
38. [Hematopoietic cell kinase (Hck) isoforms and phagocyte duties - from signaling and actin reorganization to migration and phagocytosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631)
39. [Regulation of p73 by Hck through kinase-dependent and independent mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631)
40. [Novel protein-tyrosine kinase gene (hck) preferentially expressed in cells of hematopoietic origin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08631)
41. Ensembl Release 99
42. UMLS 2023