# H2A.X variant histone

> mammalian protein found in Homo sapiens

**Wikidata**: [Q1620739](https://www.wikidata.org/wiki/Q1620739)  
**Source**: https://4ort.xyz/entity/h2a-x-variant-histone


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P16104)
3. Q20641742
4. [H2A.X. a histone isoprotein with a conserved C-terminal sequence, is encoded by a novel mRNA with both DNA replication type and polyA 3' processing signals](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104)
6. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104)
7. [Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104)
8. [Novel function of beta-arrestin2 in the nucleus of mature spermatozoa](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104)
9. [Werner syndrome helicase (WRN), nuclear DNA helicase II (NDH II) and histone gammaH2AX are localized to the centrosome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104)
10. [Phosphorylation of the Cajal body protein WRAP53β by ATM promotes its involvement in the DNA damage response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104)
11. [The proximity ligation assay reveals that at DNA double-strand breaks WRAP53β associates with γH2AX and controls interactions between RNF8 and MDC1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104)
12. [Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104)
13. [RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104)
14. [AIF promotes chromatinolysis and caspase-independent programmed necrosis by interacting with histone H2AX](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104)
15. [The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104)
16. [ChAM, a novel motif that mediates PALB2 intrinsic chromatin binding and facilitates DNA repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104)
17. [MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104)
18. [A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104)
19. [Comparison of the structures and peptide binding specificities of the BRCT domains of MDC1 and BRCA1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104)
20. [MDC1 is a mediator of the mammalian DNA damage checkpoint](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104)
21. [A-type lamins maintain the positional stability of DNA damage repair foci in mammalian nuclei](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104)
22. [Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104)
23. [Proteomic dissection of cell type-specific H2AX-interacting protein complex associated with hepatocellular carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104)
24. [Five dysfunctional telomeres predict onset of senescence in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104)
25. [Factors determining DNA double-strand break repair pathway choice in G2 phase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104)
26. [A cooperative activation loop among SWI/SNF, γ-H2AX and H3 acetylation for DNA double-strand break repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104)
27. [Structural basis of γH2AX recognition by human PTIP BRCT5-BRCT6 domains in the DNA damage response pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104)
28. [MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104)
29. [Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104)
30. [Mutant telomerase RNAs induce DNA damage and apoptosis via the TRF2-ATM pathway in telomerase-overexpressing primary fibroblasts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104)
31. [VRK1 chromatin kinase phosphorylates H2AX and is required for foci formation induced by DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104)
32. [RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104)
33. [CDK targeting of NBS1 promotes DNA-end resection, replication restart and homologous recombination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104)
34. [Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104)
35. [NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104)
36. [Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104)
37. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=P16104&geneProductId=UniProtKB:P16104)
38. [ERCC6L2 mutations link a distinct bone-marrow-failure syndrome to DNA repair and mitochondrial function](http://www.ebi.ac.uk/QuickGO/annotations?protein=P16104&geneProductId=UniProtKB:P16104)
39. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P16104&geneProductId=UniProtKB:P16104)
40. [Proteomic characterization of the human sperm nucleus](http://www.ebi.ac.uk/QuickGO/annotations?protein=P16104&geneProductId=UniProtKB:P16104)
41. [Speckled-like pattern in the germinal center (SLIP-GC), a nuclear GTPase expressed in activation-induced deaminase-expressing lymphomas and germinal center B cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P16104&geneProductId=UniProtKB:P16104)
42. [Characterization of histone H2A and H2B variants and their post-translational modifications by mass spectrometry](http://www.ebi.ac.uk/QuickGO/annotations?protein=P16104&geneProductId=UniProtKB:P16104)
43. [Depletion of nuclear histone H2A variants is associated with chronic DNA damage signaling upon drug-evoked senescence of human somatic cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P16104&geneProductId=UniProtKB:P16104)
44. [The HiNF-P/p220NPAT cell cycle signaling pathway controls nonhistone target genes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P16104&geneProductId=UniProtKB:P16104)
45. [NIMA-related protein kinase 1 is involved early in the ionizing radiation-induced DNA damage response](http://www.ebi.ac.uk/QuickGO/annotations?protein=P16104&geneProductId=UniProtKB:P16104)
46. [Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant](http://www.ebi.ac.uk/QuickGO/annotations?protein=P16104&geneProductId=UniProtKB:P16104)
47. [Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression](http://www.ebi.ac.uk/QuickGO/annotations?protein=P16104&geneProductId=UniProtKB:P16104)
48. [ERCC6L2 mutations link a distinct bone-marrow-failure syndrome to DNA repair and mitochondrial function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104)
49. [Characterization of histone H2A and H2B variants and their post-translational modifications by mass spectrometry](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104)
50. [Speckled-like pattern in the germinal center (SLIP-GC), a nuclear GTPase expressed in activation-induced deaminase-expressing lymphomas and germinal center B cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16104)