# H2A.X variant histone

> mammalian protein found in Mus musculus

**Wikidata**: [Q14912340](https://www.wikidata.org/wiki/Q14912340)  
**Source**: https://4ort.xyz/entity/h2a-x-variant-histone-q14912340


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P27661)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661)
5. [Genomic instability in mice lacking histone H2AX](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P27661&geneProductId=UniProtKB:P27661)
7. [WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661)
8. [Polycomb protein SCML2 associates with USP7 and counteracts histone H2A ubiquitination in the XY chromatin during male meiosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661)
9. [AIF promotes chromatinolysis and caspase-independent programmed necrosis by interacting with histone H2AX](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661)
10. [Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661)
11. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661)
12. [HORMAD2 is essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661)
13. [A mouse speciation gene encodes a meiotic histone H3 methyltransferase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661)
14. [Polo-like kinase is required for synaptonemal complex disassembly and phosphorylation in mouse spermatocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661)
15. [Contribution of the two genes encoding histone variant h3.3 to viability and fertility in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661)
16. [TOPAZ1, a germ cell specific factor, is essential for male meiotic progression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661)
17. [SYCP3-like X-linked 2 is expressed in meiotic germ cells and interacts with synaptonemal complex central element protein 2 and histone acetyltransferase TIP60](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661)
18. [Localization and regulation of murine Esco2 during male and female meiosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661)
19. [Disruption of Chtf18 Causes Defective Meiotic Recombination in Male Mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661)
20. [Meiotic failure in male mice lacking an X-linked factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661)
21. [Pinpointing the expression of piRNAs and function of the PIWI protein subfamily during spermatogenesis in the mouse](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661)
22. [The mouse polyubiquitin gene Ubb is essential for meiotic progression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661)
23. [Defective imprint resetting in carriers of Robertsonian translocation Rb (8.12)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661)
24. [Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661)
25. [FancJ (Brip1) loss-of-function allele results in spermatogonial cell depletion during embryogenesis and altered processing of crossover sites during meiotic prophase I in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661)
26. [Meiotic cohesin complexes are essential for the formation of the axial element in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661)
27. [Mouse HFM1/Mer3 is required for crossover formation and complete synapsis of homologous chromosomes during meiosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661)
28. [Functional conservation of Mei4 for meiotic DNA double-strand break formation from yeasts to mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661)
29. [Meiosis in mice without a synaptonemal complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661)
30. [Mouse pachytene checkpoint 2 (trip13) is required for completing meiotic recombination but not synapsis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661)
31. [Silencing of unpaired chromatin and histone H2A ubiquitination in mammalian meiosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661)
32. [Mouse maelstrom, a component of nuage, is essential for spermatogenesis and transposon repression in meiosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661)
33. [Mouse TEX15 is essential for DNA double-strand break repair and chromosomal synapsis during male meiosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661)
34. [Alignment of Homologous Chromosomes and Effective Repair of Programmed DNA Double-Strand Breaks during Mouse Meiosis Require the Minichromosome Maintenance Domain Containing 2 (MCMDC2) Protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661)
35. [NIMA-related protein kinase 1 is involved early in the ionizing radiation-induced DNA damage response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661)
36. [Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661)
37. [Deletion of genes implicated in protecting the integrity of male germ cells has differential effects on the incidence of DNA breaks and germ cell loss](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661)
38. [Silencing ofFem1cR3Gene Expression in the DBA/2J Mouse Precedes Retinal Ganglion Cell Death and Is Associated with Histone Deacetylase Activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661)
39. [The multi-copy mouse gene Sycp3-like Y-linked (Sly) encodes an abundant spermatid protein that interacts with a histone acetyltransferase and an acrosomal protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661)
40. [The Fbx4 Tumor Suppressor Regulates Cyclin D1 Accumulation and Prevents Neoplastic Transformation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661)
41. [The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661)
42. [RSPO1/β-catenin signaling pathway regulates oogonia differentiation and entry into meiosis in the mouse fetal ovary](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661)
43. [Absence of mDazl produces a final block on germ cell development at meiosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661)
44. [Expression analysis of the mouse multi-copy X-linked gene Xlr-related, meiosis-regulated (Xmr), reveals that Xmr encodes a spermatid-expressed cytoplasmic protein, SLX/XMR](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27661)
45. ensembl Release 106
46. [Identifiers.org](https://registry.identifiers.org/registry/uniprot)