# GTP cyclohydrolase 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q1487359](https://www.wikidata.org/wiki/Q1487359)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/GTP_cyclohydrolase_I)  
**Source**: https://4ort.xyz/entity/gtp-cyclohydrolase-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P30793)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793)
6. [A yeast 2-hybrid analysis of human GTP cyclohydrolase I protein interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793)
8. [GTP cyclohydrolase I utilizes metal-free GTP as its substrate](http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793)
9. [Zinc plays a key role in human and bacterial GTP cyclohydrolase I](http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793)
10. [The application of 8-aminoguanosine triphosphate, a new inhibitor of GTP cyclohydrolase I, to the purification of the enzyme from human liver](http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793)
11. [GTP cyclohydrolase I feedback regulatory protein is a pentamer of identical subunits. Purification, cDNA cloning, and bacterial expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793)
12. [Proteomic analysis of GTP cyclohydrolase 1 multiprotein complexes in cultured normal adult human astrocytes under both basal and cytokine-activated conditions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793)
13. [Toward an understanding of the protein interaction network of the human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793)
14. [GTP cyclohydrolase I mRNA: novel splice variants in the slime mould Physarum polycephalum and in human monocytes (THP-1) indicate conservation of mRNA processing](http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793)
15. [GTP cyclohydrolase feedback regulatory protein controls cofactor 6-tetrahydrobiopterin synthesis in the cytosol and in the nucleus of epidermal keratinocytes and melanocytes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793)
16. [Human GTP cyclohydrolase I: only one out of three cDNA isoforms gives rise to the active enzyme](http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793)
17. [Characterization of mouse and human GTP cyclohydrolase I genes. Mutations in patients with GTP cyclohydrolase I deficiency](http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793)
18. [Hereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase I gene](http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793)
19. [Purification of GTP cyclohydrolase I from human liver and production of specific monoclonal antibodies](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793)
20. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793)
21. [The application of 8-aminoguanosine triphosphate, a new inhibitor of GTP cyclohydrolase I, to the purification of the enzyme from human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793)
22. [GTP cyclohydrolase I utilizes metal-free GTP as its substrate](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793)
23. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793)
24. [Zinc plays a key role in human and bacterial GTP cyclohydrolase I](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793)
25. [GTP cyclohydrolase feedback regulatory protein controls cofactor 6-tetrahydrobiopterin synthesis in the cytosol and in the nucleus of epidermal keratinocytes and melanocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793)
26. [Characterization of mouse and human GTP cyclohydrolase I genes. Mutations in patients with GTP cyclohydrolase I deficiency](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793)
27. [Hereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase I gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793)
28. [Specific localization of the guanosine triphosphate (GTP) cyclohydrolase I-immunoreactivity in the human brain](http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793)
29. [Localization of GTP cyclohydrolase I in human peripheral blood smears using a specific monoclonal antibody and an immune-alkaline phosphatase labeling technique](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793)
30. [The neurobiology of tetrahydrobiopterin biosynthesis: A model for regulation of GTP cyclohydrolase I gene transcription within nigrostriatal dopamine neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793)
31. [3' deletions cause aniridia by preventing PAX6 gene expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793)
32. [Specific localization of the guanosine triphosphate (GTP) cyclohydrolase I-immunoreactivity in the human brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793)
33. [Cytokines Stimulate GTP Cyclohydrolase I Gene Expression in Cultured Human Umbilical Vein Endothelial Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793)
34. [Pteridine biosynthesis in human endothelial cells. Impact on nitric oxide-mediated formation of cyclic GMP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793)
35. [Role of human GTP cyclohydrolase I and its regulatory protein in tetrahydrobiopterin metabolism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793)
36. [The assays of activities and function of TH, AADC, and GCH1 and their potential use in ex vivo gene therapy of PD](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793)
37. [Augmented BH4 by gene transfer restores nitric oxide synthase function in hyperglycemic human endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793)
38. [Discovery of common human genetic variants of GTP cyclohydrolase 1 (GCH1) governing nitric oxide, autonomic activity, and cardiovascular risk](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793)
39. [Cytokine-stimulated GTP cyclohydrolase I expression in endothelial cells requires coordinated activation of nuclear factor-kappaB and Stat1/Stat3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793)
40. [Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793)
41. [GTP cyclohydrolase I gene transfer augments intracellular tetrahydrobiopterin in human endothelial cells: effects on nitric oxide synthase activity, protein levels and dimerisation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793)
42. [Novel mutations in the guanosine triphosphate cyclohydrolase 1 gene associated with DYT5 dystonia](http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793)
43. [Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways](http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793)
44. [Cytokines Stimulate GTP Cyclohydrolase I Gene Expression in Cultured Human Umbilical Vein Endothelial Cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793)
45. [Pteridine biosynthesis in human endothelial cells. Impact on nitric oxide-mediated formation of cyclic GMP](http://www.ebi.ac.uk/QuickGO/annotations?protein=P30793&geneProductId=UniProtKB:P30793)
46. [Novel mutations in the guanosine triphosphate cyclohydrolase 1 gene associated with DYT5 dystonia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30793)
47. Ensembl Release 99
48. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)