# GTP cyclohydrolase 1

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28558105](https://www.wikidata.org/wiki/Q28558105)  
**Source**: https://4ort.xyz/entity/gtp-cyclohydrolase-1-q28558105


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P22288)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288)
5. [Rat GTP cyclohydrolase I is a homodecameric protein complex containing high-affinity calcium-binding sites](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288)
6. [Induction of GTP cyclohydrolase I by bacterial lipopolysaccharide in the rat](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288)
7. [Enhanced expression of GTP cyclohydrolase I in V-1-overexpressing PC12D cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288)
8. [Purification and cloning of the GTP cyclohydrolase I feedback regulatory protein, GFRP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288)
9. [The mechanism of potent GTP cyclohydrolase I inhibition by 2,4-diamino-6-hydroxypyrimidine: requirement of the GTP cyclohydrolase I feedback regulatory protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288)
10. [Purification and characterization of rat liver GTP cyclohydrolase I. Cooperative binding of GTP to the enzyme](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288)
11. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288)
12. [Identification of a rabphilin-3A-interacting protein as GTP cyclohydrolase I in PC12 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288)
13. [Structural basis of biopterin-induced inhibition of GTP cyclohydrolase I by GFRP, its feedback regulatory protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288)
14. [Crystal structure of the stimulatory complex of GTP cyclohydrolase I and its feedback regulatory protein GFRP.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288)
15. [Decameric GTP Cyclohydrolase I Forms Complexes with Two Pentameric GTP Cyclohydrolase I Feedback Regulatory Proteins in the Presence of Phenylalanine or of a Combination of Tetrahydrobiopterin and GTP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288)
16. [The Protein Partners of GTP Cyclohydrolase I in Rat Organs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288)
17. [GTP cyclohydrolase 1 inhibition attenuates vasodilation and increases blood pressure in rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288)
18. [GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22288)
19. ensembl Release 106