# Growth factor receptor bound protein 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q5514416](https://www.wikidata.org/wiki/Q5514416)  
**Source**: https://4ort.xyz/entity/growth-factor-receptor-bound-protein-2


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P62993)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993)
5. [GAREM, a novel adaptor protein for growth factor receptor-bound protein 2, contributes to cellular transformation through the activation of extracellular signal-regulated kinase signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993)
6. [HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993)
7. [A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993)
8. [Bivalent binding drives the formation of the Grb2-Gab1 signaling complex in a noncooperative manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993)
9. [Inhibition of basal FGF receptor signaling by dimeric Grb2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993)
10. [TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993)
11. [unc-53 controls longitudinal migration in C. elegans](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993)
12. [SCIMP, a transmembrane adaptor protein involved in major histocompatibility complex class II signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993)
13. [Histidine domain-protein tyrosine phosphatase interacts with Grb2 and GrpL](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993)
14. [FCRL6 receptor: expression and associated proteins.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993)
15. [KIF26A is an unconventional kinesin and regulates GDNF-Ret signaling in enteric neuronal development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993)
16. [Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993)
17. [Generation of novel cytoplasmic forms of protein tyrosine phosphatase epsilon by proteolytic processing and translational control](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993)
18. [The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993)
19. [Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993)
20. [RHEX, a novel regulator of human erythroid progenitor cell expansion and erythroblast development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993)
21. [PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993)
22. [Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993)
23. [Shc phosphotyrosine-binding domain dominantly interacts with epidermal growth factor receptors and mediates Ras activation in intact cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993)
24. [Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993)
25. [The Grb2-mSos1 complex binds phosphopeptides with higher affinity than Grb2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993)
26. [LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993)
27. [The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993)
28. [Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993)
29. [Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993)
30. [Charting the molecular network of the drug target Bcr-Abl](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993)
31. [The central proline rich region of POB1/REPS2 plays a regulatory role in epidermal growth factor receptor endocytosis by binding to 14-3-3 and SH3 domain-containing proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993)
32. [The Shc adaptor protein is highly phosphorylated at conserved, twin tyrosine residues (Y239/240) that mediate protein-protein interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993)
33. [SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993)
34. [Functional interaction between c-Src and its mitotic target, Sam 68](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993)
35. [Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993)
36. [Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993)
37. [SH3 domains of Grb2 adaptor bind to PXpsiPXR motifs within the Sos1 nucleotide exchange factor in a discriminate manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993)
38. [FCH domain only-2 organizes clathrin-coated structures and interacts with Disabled-2 for low-density lipoprotein receptor endocytosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993)
39. [Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993)
40. [Translationally controlled tumor protein induces human breast epithelial cell transformation through the activation of Src](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993)
41. [The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993)
42. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993)
43. [Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993)
44. [Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993)
45. [A single PXXP motif in the C‐terminal region of srGAP3 mediates binding to multiple SH3 domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993)
46. [Characterization of VIK-1: a new Vav-interacting Kruppel-like protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993)
47. [A Src homology 3-binding sequence on the C terminus of Sprouty2 is necessary for inhibition of the Ras/ERK pathway downstream of fibroblast growth factor receptor stimulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993)
48. [Co-expression with BCR induces activation of the FES tyrosine kinase and phosphorylation of specific N-terminal BCR tyrosine residues](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993)
49. [Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993)
50. [Evidence of LAT as a dual substrate for Lck and Syk in T lymphocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62993)