# Growth factor receptor bound protein 10

> mammalian protein found in Homo sapiens

**Wikidata**: [Q5514411](https://www.wikidata.org/wiki/Q5514411)  
**Source**: https://4ort.xyz/entity/growth-factor-receptor-bound-protein-10-q5514411


## References

1. UniProt
2. Q20641742
3. [Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322)
4. [Critical involvement of RQCD1 in the EGFR-Akt pathway in mammary carcinogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322)
5. [Phosphorylation of grb10 regulates its interaction with 14-3-3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322)
6. [GIGYF2 is present in endosomal compartments in the mammalian brains and enhances IGF-1-induced ERK1/2 activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322)
7. [Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322)
8. [Phospho-tyrosine dependent protein-protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322)
9. [FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322)
10. [Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology [...]](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322)
11. [Distinct Grb10 domain requirements for effects on glucose uptake and insulin signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322)
12. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322)
13. [Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13322&geneProductId=UniProtKB:Q13322)
14. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322)
15. [Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322)
16. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13322&geneProductId=UniProtKB:Q13322)
17. [GRB10 binds to LRP6, the Wnt co-receptor and inhibits canonical Wnt signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322)
18. [Grb10 promotes lipolysis and thermogenesis by phosphorylation-dependent feedback inhibition of mTORC1.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322)
19. Ensembl Release 99
20. Identifiers.org
21. UMLS 2023