Growth differentiation factor 5
type: Thing
description: mammalian protein found in Mus musculus
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P352
  value: P43027
additional property: PropertyValue
  property ID: P361
  value: Transforming growth factor-beta-related
additional property: PropertyValue
  property ID: P361
  value: Cystine-knot cytokine
additional property: PropertyValue
  property ID: P361
  value: membrane protein
additional property: PropertyValue
  property ID: P527
  value: Transforming growth factor beta, conserved site
additional property: PropertyValue
  property ID: P527
  value: Transforming growth factor-beta, C-terminal
additional property: PropertyValue
  property ID: P527
  value: TGF-beta, propeptide
additional property: PropertyValue
  property ID: P637
  value: NP_032135
additional property: PropertyValue
  property ID: P680
  value: cytokine activity
additional property: PropertyValue
  property ID: P680
  value: BMP binding
additional property: PropertyValue
  property ID: P680
  value: protein binding
additional property: PropertyValue
  property ID: P681
  value: membrane
additional property: PropertyValue
  property ID: P681
  value: plasma membrane
additional property: PropertyValue
  property ID: P681
  value: extracellular region
additional property: PropertyValue
  property ID: P682
  value: negative regulation of mesenchymal cell apoptotic process
additional property: PropertyValue
  property ID: P682
  value: forelimb morphogenesis
additional property: PropertyValue
  property ID: P682
  value: regulation of MAPK cascade
additional property: PropertyValue
  property ID: P702
  value: Gdf5
additional property: PropertyValue
  property ID: P703
  value: house mouse
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000048079
confidence:
  popularity graph score:
    score: 0.002
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 14
      unique citations norm: 0.006
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 14
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: P43027
    source count: 1
    confidence: 0.2
  P361:
    value: Q24724932
    source count: 1
    confidence: 0.2
    value label: Transforming growth factor-beta-related
  P361:
    value: Q24783539
    source count: 1
    confidence: 0.2
    value label: Cystine-knot cytokine
  P361:
    value: Q423042
    source count: 1
    confidence: 0.2
    value label: membrane protein
  P361:
    value: Q83133008
    source count: 1
    confidence: 0.2
    value label: Transforming growth factor-beta, C-terminal domain, protein family
  P361:
    value: Q83163860
    source count: 1
    confidence: 0.2
    value label: TGF-beta, propeptide family
  P527:
    value: Q24725603
    source count: 1
    confidence: 0.2
    value label: Transforming growth factor beta, conserved site
  P527:
    value: Q24721300
    source count: 1
    confidence: 0.2
    value label: Transforming growth factor-beta, C-terminal
  P527:
    value: Q24784051
    source count: 1
    confidence: 0.2
    value label: TGF-beta, propeptide
  P637:
    value: NP_032135
    source count: 1
    confidence: 0.2
  P680:
    value: Q14862699
    source count: 2
    confidence: 0.4
    value label: cytokine activity
  P680:
    value: Q14914474
    source count: 2
    confidence: 0.4
    value label: BMP binding
  P680:
    value: Q167149
    source count: 3
    confidence: 0.6
    value label: protein binding
  P680:
    value: Q14762994
    source count: 2
    confidence: 0.4
    value label: identical protein binding
  P680:
    value: Q14903935
    source count: 1
    confidence: 0.2
    value label: transforming growth factor beta receptor binding
  P681:
    value: Q14349455
    source count: 1
    confidence: 0.2
    value label: membrane
  P681:
    value: Q29548
    source count: 1
    confidence: 0.2
    value label: plasma membrane
  P681:
    value: Q14645596
    source count: 1
    confidence: 0.2
    value label: extracellular region
  P681:
    value: Q1385443
    source count: 2
    confidence: 0.4
    value label: extracellular space
  P682:
    value: Q14912050
    source count: 1
    confidence: 0.2
    value label: negative regulation of mesenchymal cell apoptotic process
  P682:
    value: Q14912045
    source count: 1
    confidence: 0.2
    value label: forelimb morphogenesis
  P682:
    value: Q14859574
    source count: 1
    confidence: 0.2
    value label: regulation of MAPK cascade
  P682:
    value: Q14858821
    source count: 3
    confidence: 0.6
    value label: SMAD protein signal transduction

value: Q14877672
source count: 1
confidence: 0.2
value label: chondrocyte differentiation

value: Q14912048
source count: 1
confidence: 0.2
value label: Gdf5

value: Q83310
source count: 1
confidence: 0.2
value label: house mouse

value: ENSMUSP00000048079
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-05-09

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-05-09

source: Developmentally regulated expression of mouse HtrA3 and its role as an inhibitor of TGF-beta signaling
stated in qid: Q28512559
retrieved: 2019-05-09

source: A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage
stated in qid: Q28189811
retrieved: 2019-05-09

source: HtrA1 serine protease inhibits signaling mediated by Tgfbeta family proteins
stated in qid: Q28245903
retrieved: 2019-05-09

source: Developmental failure of phalanges in the absence of growth/differentiation factor 5
stated in qid: Q28589484
retrieved: 2019-05-09

source: Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily
stated in qid: Q28251546
retrieved: 2019-05-09

source: Trps1 plays a pivotal role downstream of Gdf5 signaling in promoting chondrogenesis and apoptosis of ATDC5 cells
stated in qid: Q28506617
retrieved: 2019-02-14

source: Identification of mutation in the growth differentiation factor 5 (Gdf5) gene in NC-brp/brp mice
stated in qid: Q28592000
retrieved: 2019-05-09

source: Role of CDMP-1 in skeletal morphogenesis: promotion of mesenchymal cell recruitment and chondrocyte differentiation
stated in qid: Q28594745
retrieved: 2019-02-14

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2022-05-25

source: Q20641742
stated in qid: Q20641742
retrieved: 2022-03-20

source: ensembl Release 106
stated in qid: Q111699881

wikidata id: Q14912051
domain: protein
level: standard
html url: https://4ort.xyz/entity/growth-differentiation-factor-5
markdown url: https://4ort.xyz/entity/growth-differentiation-factor-5.md
facts url summary: https://4ort.xyz/entity/growth-differentiation-factor-5/facts.json
facts url standard: https://4ort.xyz/entity/growth-differentiation-factor-5/facts.json
facts url full: https://4ort.xyz/entity/growth-differentiation-factor-5/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-24T03:46:06.417451Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T13:57:37.732274+00:00Z