# growth differentiation factor 5

> mammalian protein found in Homo sapiens

**Wikidata**: [Q5513078](https://www.wikidata.org/wiki/Q5513078)  
**Source**: https://4ort.xyz/entity/growth-differentiation-factor-5-q5513078


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P43026)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026)
5. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026)
6. [New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026)
7. [A GDF5 point mutation strikes twice--causing BDA1 and SYNS2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026)
8. [Targeting of bone morphogenetic protein growth factor complexes to fibrillin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026)
9. [Activating and deactivating mutations in the receptor interaction site of GDF5 cause symphalangism or brachydactyly type A2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026)
10. [Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026)
11. [Biophysical and structural characterization of a folded core domain within the proregion of growth and differentiation factor-5](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026)
12. [A human chondrodysplasia due to a mutation in a TGF-beta superfamily member](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026)
13. [Molecular analysis of two novel missense mutations in the GDF5 proregion that reduce protein activity and are associated with brachydactyly type C](http://www.ebi.ac.uk/QuickGO/annotations?protein=P43026&geneProductId=UniProtKB:P43026)
14. [New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance](http://www.ebi.ac.uk/QuickGO/annotations?protein=P43026&geneProductId=UniProtKB:P43026)
15. [Molecular analysis of two novel missense mutations in the GDF5 proregion that reduce protein activity and are associated with brachydactyly type C](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026)
16. [Bone morphogenetic proteins and growth and differentiation factors in the human cornea](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026)
17. [Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-beta superfamily predominantly expressed in long bones during human embryonic development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026)
18. Ensembl Release 99
19. UMLS 2023