# Growth differentiation factor 15

> mammalian protein found in Homo sapiens

**Wikidata**: [Q74581](https://www.wikidata.org/wiki/Q74581)  
**Source**: https://4ort.xyz/entity/growth-differentiation-factor-15


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q99988)
3. Q20641742
4. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988)
6. [NAG-1/GDF15 accumulates in the nucleus and modulates transcriptional regulation of the Smad pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988)
7. [Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988)
8. [GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988)
9. [The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988)
10. [An empirical framework for binary interactome mapping](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988)
11. [MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988)
12. [Long-acting MIC-1/GDF15 molecules to treat obesity: Evidence from mice to monkeys.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988)
13. [MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99988&geneProductId=UniProtKB:Q99988)
14. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99988&geneProductId=UniProtKB:Q99988)
15. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99988&geneProductId=UniProtKB:Q99988)
16. [Proteomic analysis of podocyte exosome-enriched fraction from normal human urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99988&geneProductId=UniProtKB:Q99988)
17. [NAG-1/GDF15 accumulates in the nucleus and modulates transcriptional regulation of the Smad pathway](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99988&geneProductId=UniProtKB:Q99988)
18. [GDF15 is a heart-derived hormone that regulates body growth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988)
19. [Comprehensive proteomic characterization of stem cell-derived extracellular matrices](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988)
20. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988)
21. [Human cDNA Encoding a Novel TGF- Superfamily Protein Highly Expressed in Placenta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988)
22. [GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99988)
23. Ensembl Release 99
24. Identifiers.org
25. UMLS 2023